利用TCR-CAR双信号进行精准癌症靶向治疗。
Using TCR-CAR dual signaling for precise cancer targeting.
作者信息
Shahbazy Mohammad, Leo Isabelle Rose, Faridi Pouya, Caron Etienne
机构信息
Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Clinical Proteomics Mass Spectrometry, Department of Oncology-Pathology, Karolinska Institutet, Science for Life Laboratory, Solna, Sweden.
出版信息
Trends Immunol. 2025 Jun;46(6):435-437. doi: 10.1016/j.it.2025.04.007. Epub 2025 May 13.
Recently, Kondo et al. engineered the coexpression of a T cell receptor (TCR) and a chimeric antigen receptor (CAR) and developed an antagonism-enforced braking system where TCR signals both enhance and inhibit CAR activation. This work may enable rational design of CAR-T agents that limit toxicity to healthy tissue.
最近，近藤等人设计了一种T细胞受体（TCR）和嵌合抗原受体（CAR）的共表达，并开发了一种拮抗增强制动系统，其中TCR信号既增强又抑制CAR激活。这项工作可能有助于合理设计对健康组织毒性有限的CAR-T药物。
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