Shahbazy Mohammad, Leo Isabelle Rose, Faridi Pouya, Caron Etienne
Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Clinical Proteomics Mass Spectrometry, Department of Oncology-Pathology, Karolinska Institutet, Science for Life Laboratory, Solna, Sweden.
Trends Immunol. 2025 Jun;46(6):435-437. doi: 10.1016/j.it.2025.04.007. Epub 2025 May 13.
Recently, Kondo et al. engineered the coexpression of a T cell receptor (TCR) and a chimeric antigen receptor (CAR) and developed an antagonism-enforced braking system where TCR signals both enhance and inhibit CAR activation. This work may enable rational design of CAR-T agents that limit toxicity to healthy tissue.
最近，近藤等人设计了一种T细胞受体（TCR）和嵌合抗原受体（CAR）的共表达，并开发了一种拮抗增强制动系统，其中TCR信号既增强又抑制CAR激活。这项工作可能有助于合理设计对健康组织毒性有限的CAR-T药物。
