Baba Taro, Hirooka Kazuyuki, Okada Naoki, Onoe Hiromitsu, Tokumo Kana, Okumichi Hideaki, Kiuchi Yoshiaki, Sakaguchi Hirokazu
Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan.
Department of Ophthalmology, Yoshijima Hospital, Hiroshima, Japan.
Sci Rep. 2025 May 14;15(1):16748. doi: 10.1038/s41598-025-01550-w.
In this retrospective study, we evaluated changes in corneal higher-order aberrations (HOAs) after PreserFlo MicroShunt (PFM) implantation and examined factors associated with the outcomes. We included 101 PFM implantations performed between February 2023 and June 2024. Visual acuity, intraocular pressure, corneal HOAs, and coma-like and spherical aberrations were analyzed preoperatively, at 1 week, and at 1, 2, and 3 months postoperatively. Generalized linear mixed models were used to analyze factors that might affect HOAs and other aberrations. Preoperatively, HOAs, coma-like aberrations, and spherical-like aberrations were 0.249 ± 0.192, 0.216 ± 0.180, and 0.109 ± 0.093 μm, respectively. Aberrations showed a significant increase up to 1 month postoperatively, peaking at 1 week, with values of 0.396 ± 0.210 μm, 0.346 ± 0.204 μm, and 0.173 ± 0.105 μm, respectively (all P < 0.001). The aberrations were no longer significantly greater than baseline at 2 and 3 months postoperatively. Analysis of risk factors suggested that post-implantation hypotony (≤ 5 mmHg) could influence corneal HOAs and coma-like aberrations. PFM implantation temporarily increased corneal HOAs, coma-like aberrations, and spherical aberrations, but these levels stabilized and had returned to preoperative levels by 2 months postoperatively. Postoperative hypotony was associated with increased corneal HOAs and coma-like aberrations.
在这项回顾性研究中，我们评估了PreserFlo微型分流器（PFM）植入术后角膜高阶像差（HOAs）的变化，并研究了与手术结果相关的因素。我们纳入了2023年2月至2024年6月期间进行的101例PFM植入手术。在术前、术后1周以及术后1、2和3个月对视力、眼压、角膜HOAs以及类彗差和球差进行了分析。使用广义线性混合模型分析可能影响HOAs和其他像差的因素。术前，HOAs、类彗差和类球差分别为0.249±0.192、0.216±0.180和0.109±0.093μm。像差在术后1个月内显著增加，在术后1周达到峰值，分别为0.396±0.210μm、0.346±0.204μm和0.173±0.105μm（所有P<0.001）。术后2个月和3个月时，像差不再显著高于基线水平。危险因素分析表明，植入后低眼压（≤5 mmHg）可能影响角膜HOAs和类彗差。PFM植入术使角膜HOAs、类彗差和球差暂时增加，但这些水平在术后2个月时趋于稳定并恢复到术前水平。术后低眼压与角膜HOAs和类彗差增加有关。
