Allen M L, Orr W C, Woodruff D M, Duke J C, Robinson M G
Am J Gastroenterol. 1985 Sep;80(9):669-72.
Fourteen volunteers were studied on two occasions to assess the effect of swallowing frequency on acid clearance time. The experimental protocol consisted of two trials of infusion of 15 ml of 0.1 N HCl into the distal esophagus. One trial required swallowing every 30 s for 10 min. The other trial involved an initial rapid swallowing rate (seven swallows in the 1st min) with a gradual predetermined decline in rate. This procedure was repeated 12 h after application of a transdermal scopolamine patch. Baseline clearance times for rapid and slow swallowing were not significantly different. The anticholinergic drug significantly prolonged the clearance times for both rapid and slow swallowing. Under baseline conditions, sequential swallows (after the first three to four swallows) produced a significant rise in pH until the clearance criterion of pH 4.0 was reached. This effect was abolished with the anticholinergic drug. These results support a two-stage model of acid clearance with initial volume clearance and subsequent salivary buffering of residual intraesophageal acid.
对14名志愿者进行了两次研究，以评估吞咽频率对酸清除时间的影响。实验方案包括两次向食管远端注入15毫升0.1N盐酸的试验。一次试验要求每30秒吞咽一次，持续10分钟。另一次试验则是开始时吞咽速度较快（第1分钟吞咽7次），随后按照预先确定的速率逐渐下降。在应用透皮东莨菪碱贴片12小时后重复此过程。快速吞咽和慢速吞咽的基线清除时间无显著差异。抗胆碱能药物显著延长了快速吞咽和慢速吞咽的清除时间。在基线条件下，连续吞咽（前三到四次吞咽后）会使pH值显著升高，直至达到pH 4.0的清除标准。抗胆碱能药物消除了这种效应。这些结果支持了酸清除的两阶段模型，即初始的容量清除和随后对残留食管内酸的唾液缓冲作用。
