复发性肾母细胞瘤治疗中尚存的挑战：儿童肿瘤学组和国际儿科肿瘤学会观点
Remaining Challenges in the Treatment of Relapsed Wilms Tumor: Children's Oncology Group and International Society of Paediatric Oncology Perspectives.
作者信息
Sutton Kathryn S, Walz Amy L, Groenendijk Alissa, Murphy Andrew J, Pater Luke, Janssens Geert O, Brzezinski Jack, Mullen Elizabeth A, Spreafico Filippo, Godzinski Jan, van der Beek Justine, Hwa Wijnen Marc, van den Heuvel-Eibrink Marry M, Pachl Max, Graf Norbert, Ehrlich Peter F, Furtwangler Rhoikos, Brok Jesper, Geller James
机构信息
Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
出版信息
Pediatr Blood Cancer. 2025 Aug;72(8):e31790. doi: 10.1002/pbc.31790. Epub 2025 May 14.
Wilms tumor (WT) is the most common pediatric renal tumor, and with multidisciplinary treatment overall outcomes are excellent. However, a small subset of patients with WT will relapse. The ideal treatment of relapsed WT is yet to be defined. Ongoing studies through the Children's Oncology Group Renal Tumors Committee (COG-RTC) and the International Society of Paediatric Oncology Renal Tumor Study Group (SIOP-RTSG) aim to improve risk stratification and treatment strategies. Members met at the SIOP 55th Annual Congress 2023 to outline available data and knowledge gaps and develop future research priorities.
肾母细胞瘤（WT）是最常见的小儿肾肿瘤，通过多学科治疗，总体预后良好。然而，一小部分WT患者会复发。复发WT的理想治疗方法尚未确定。通过儿童肿瘤学组肾肿瘤委员会（COG-RTC）和国际小儿肿瘤学会肾肿瘤研究组（SIOP-RTSG）正在进行的研究旨在改善风险分层和治疗策略。成员们在2023年第55届SIOP年会上会面，概述现有数据和知识空白，并制定未来的研究重点。
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