Markov A K, Oglethorpe N, Terry J, Grogan J B, Hellems H K
Am J Med Sci. 1985 Jul;290(1):3-10. doi: 10.1097/00000441-198507000-00002.
The phagocytic behavior of the reticuloendothelial system in the rat was assessed by a quantitative technique following fructose-1,6-diphosphate (FDP) administration. In addition, the effect of FDP on the carbohydrate metabolism of human leukocytes was investigated. The rate of colloidal carbon clearance from the blood was increased significantly in the FDP-treated rats as compared to dextrose and saline controls (p less than 0.001). FDP also attenuated the hepatic decrease of ATP (p less than 0.005) and creatine phosphate (p less than 0.005) that has been observed after intravenous administration of colloidal carbon. Carbohydrate metabolism in human leukocytes was enhanced by FDP, with a concomitant increase in ATP content (p less than 0.001). Experimental evidence suggests that FDP intervenes in the Embden-Meyerhof pathway both as a metabolic regulator and as a high energy substrate. These properties of FDP in stimulating the carbohydrate metabolism have recently been described in man.
通过一种定量技术评估了果糖-1,6-二磷酸（FDP）给药后大鼠网状内皮系统的吞噬行为。此外，还研究了FDP对人白细胞碳水化合物代谢的影响。与葡萄糖和生理盐水对照组相比，FDP处理的大鼠血液中胶体碳的清除率显著提高（p<0.001）。FDP还减轻了静脉注射胶体碳后观察到的肝脏中ATP（p<0.005）和磷酸肌酸（p<0.005）的降低。FDP增强了人白细胞中的碳水化合物代谢，同时ATP含量增加（p<0.001）。实验证据表明，FDP作为代谢调节剂和高能底物参与糖酵解途径。FDP在刺激碳水化合物代谢方面的这些特性最近在人体中也有描述。
