Burnett J C, Haas J A, Larson M S
Am J Physiol. 1985 Sep;249(3 Pt 2):F396-9. doi: 10.1152/ajprenal.1985.249.3.F396.
Studies were performed in normal and DOCA-treated rats to determine renal hydrostatic pressures within superficial peritubular capillaries, the vasa recta, and renal interstitium during mineralocorticoid escape to test the hypothesis that mineralocorticoid escape is associated with elevated renal interstitial hydrostatic pressure. Fractional sodium excretion was greater in the DOCA-treated rats (3.20 +/- 0.51%) compared with control rats (1.23 +/- 0.12%) with no difference in glomerular filtration rate and renal blood flow between the two groups. Superficial peritubular capillary hydrostatic pressure (13.4 +/- 0.6 vs. 8.3 +/- 0.3 mmHg), vasa recta hydrostatic pressure (13.8 +/- 0.5 vs. 9.0 +/- 0.4 mmHg), renal interstitial hydrostatic pressure (9.8 +/- 0.4 vs. 4.5 +/- 0.4 mmHg), and arterial pressure (145 +/- 6 vs. 120 +/- 7 mmHg) were greater in the DOCA-treated compared with the control rats. These studies establish that mineralocorticoid escape is characterized by high renal interstitial hydrostatic pressure.
在正常大鼠和接受去氧皮质酮（DOCA）治疗的大鼠中进行了研究，以确定在盐皮质激素逃逸期间浅表肾小管周围毛细血管、直小血管和肾间质内的肾静水压力，从而验证盐皮质激素逃逸与肾间质静水压力升高相关的假说。与对照大鼠（1.23±0.12%）相比，接受DOCA治疗的大鼠的钠排泄分数更高（3.20±0.51%），两组之间的肾小球滤过率和肾血流量没有差异。与对照大鼠相比，接受DOCA治疗的大鼠的浅表肾小管周围毛细血管静水压力（13.4±0.6对8.3±0.3 mmHg）、直小血管静水压力（13.8±0.5对9.0±0.4 mmHg）、肾间质静水压力（9.8±0.4对4.5±0.4 mmHg）和动脉压（145±6对120±7 mmHg）更高。这些研究表明，盐皮质激素逃逸的特征是肾间质静水压力升高。
