口服营养补充剂和聚对苯二甲酸乙二酯-聚芳酯膜替代透析期间肠外营养对终末期肾病维持性血液透析患者营养状况的影响

Effects of Replacing Intradialytic Parenteral Nutrition by Oral Nutritional Supplements and Polyester-Polyarylate Membrane on Nutritional Status in Maintenance Hemodialysis Patients with End-Stage Kidney Disease.

作者信息

Hoffmann Maxime, Ben Henda Amaury, Mazouz Omar, Amaria Rachid

机构信息

Department of Nephrology, La Louviere Private Hospital, Lille, France.

Department of Nephrology, Bois-Bernard Private Hospital, Bois-Bernard, France.

出版信息

Biomed Hub. 2025 Apr 3;10(1):98-104. doi: 10.1159/000545460. eCollection 2025 Jan-Dec.

DOI:10.1159/000545460

PMID:40371013

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12077863/

Abstract

INTRODUCTION

In patients receiving hemodialysis, protein-energy wasting may be frequent and is associated with nutritional and metabolic alterations. This study aimed to describe the effects of a new therapeutic strategy, i.e., oral nutritional supplements (ONS) associated with a polyester-polyarylate (PEPA) membrane, on nutritional markers in high-risk patients with intradialytic parenteral nutrition (IDPN) history.

METHODS

Patients, who received individually IDPN (M-6 to M0) then ONS (M0 to M6), were followed over a 12-month period.

RESULTS

There was no change in serum albumin over time. The BMI increased between M-6 and M6. Food intake showed increase between M0 and M3. Quality-of-life score was stable between M0 and M6. None of the adverse events was judged related to ONS, PEPA, or research procedure.

CONCLUSION

This study focusing on a new therapeutic strategy composed of ONS and PEPA membrane replacing IDPN to maintain nutritional markers in high-risk patients receiving hemodialysis might warrant further research with robust methodology.

摘要