口服营养补充剂和聚对苯二甲酸乙二酯-聚芳酯膜替代透析期间肠外营养对终末期肾病维持性血液透析患者营养状况的影响
Effects of Replacing Intradialytic Parenteral Nutrition by Oral Nutritional Supplements and Polyester-Polyarylate Membrane on Nutritional Status in Maintenance Hemodialysis Patients with End-Stage Kidney Disease.
作者信息
Hoffmann Maxime, Ben Henda Amaury, Mazouz Omar, Amaria Rachid
机构信息
Department of Nephrology, La Louviere Private Hospital, Lille, France.
Department of Nephrology, Bois-Bernard Private Hospital, Bois-Bernard, France.
出版信息
Biomed Hub. 2025 Apr 3;10(1):98-104. doi: 10.1159/000545460. eCollection 2025 Jan-Dec.
INTRODUCTION
In patients receiving hemodialysis, protein-energy wasting may be frequent and is associated with nutritional and metabolic alterations. This study aimed to describe the effects of a new therapeutic strategy, i.e., oral nutritional supplements (ONS) associated with a polyester-polyarylate (PEPA) membrane, on nutritional markers in high-risk patients with intradialytic parenteral nutrition (IDPN) history.
METHODS
Patients, who received individually IDPN (M-6 to M0) then ONS (M0 to M6), were followed over a 12-month period.
RESULTS
There was no change in serum albumin over time. The BMI increased between M-6 and M6. Food intake showed increase between M0 and M3. Quality-of-life score was stable between M0 and M6. None of the adverse events was judged related to ONS, PEPA, or research procedure.
CONCLUSION
This study focusing on a new therapeutic strategy composed of ONS and PEPA membrane replacing IDPN to maintain nutritional markers in high-risk patients receiving hemodialysis might warrant further research with robust methodology.
引言
在接受血液透析的患者中，蛋白质能量消耗可能很常见，并且与营养和代谢改变有关。本研究旨在描述一种新的治疗策略，即口服营养补充剂（ONS）联合聚对苯二甲酸乙二酯-聚芳酯（PEPA）膜，对有透析期间肠外营养（IDPN）史的高危患者营养指标的影响。
方法
对先接受个体化IDPN（M-6至M0）然后接受ONS（M0至M6）的患者进行为期12个月的随访。
结果
血清白蛋白水平随时间无变化。BMI在M-6至M6之间升高。食物摄入量在M0至M3之间增加。生活质量评分在M0至M6之间稳定。未判定有任何不良事件与ONS、PEPA或研究程序有关。
结论
这项针对由ONS和PEPA膜组成的新治疗策略（替代IDPN以维持接受血液透析的高危患者的营养指标）的研究，可能需要采用更可靠的方法进行进一步研究。
Zotero 插件