Lo Lillian, Masson Sarah, Brons Matthew, Leung Benjamin
PharmD, ACPR, RPh, is a Clinical Pharmacist with Royal Columbian Hospital, Lower Mainland Pharmacy Services (Fraser Health Authority), New Westminster, British Columbia.
BSc, BSc(Pharm), ACPR, RPh, is Clinical Pharmacy Supervisor with Ridge Meadows Hospital, Lower Mainland Pharmacy Services (Fraser Health Authority), Maple Ridge, British Columbia.
Can J Hosp Pharm. 2025 May 14;78(2):e3708. doi: 10.4212/cjhp.3708. eCollection 2025.
Greater burdens of comorbidity and exposure to unique environmental factors predispose incarcerated individuals to polypharmacy and inappropriate prescribing. There is limited literature investigating polypharmacy within the correctional health setting.
To determine the median number of medications prescribed per client at facilities in British Columbia, to determine the proportion of clients meeting the definition for polypharmacy, to identify the top medication categories prescribed, and to screen for potential drug therapy problems among those with polypharmacy.
An observational point prevalence study of adult clients with one or more active medications on the census date at 5 correctional health facilities in British Columbia was conducted. Clients were excluded if they had one-time or no medication orders on the census date.
Of the 500 clients screened, 420 were included in the final analysis. Across the centres, the median number of medications ranged from 3 to 5 per client, and the rate of polypharmacy ranged from 23% to 41%. Of the scheduled medications, opioid agonist therapy and psychotropics were the leading categories prescribed across all facilities. Non-opioid analgesics were the top "as needed" medications prescribed at 4 of the 5 facilities. The leading potential drug therapy problem identified was drug interactions resulting in additive sedation.
Polypharmacy was present within all facilities in this study, with more than 25% of clients affected at 3 of the sites. The top medications prescribed aligned with those identified in the literature; however, there remain opportunities for therapy optimization.
合并症负担加重以及接触独特的环境因素,使被监禁者更容易出现多药联用和不适当用药的情况。在惩教卫生环境中,研究多药联用的文献有限。
确定不列颠哥伦比亚省各机构每位患者开具的药物中位数,确定符合多药联用定义的患者比例,确定开具的主要药物类别,并筛查多药联用患者中潜在的药物治疗问题。
对不列颠哥伦比亚省5个惩教卫生机构中在普查日期有1种或多种正在使用药物的成年患者进行观察性现患率研究。如果患者在普查日期有一次性用药医嘱或无用药医嘱,则将其排除。
在筛查的500名患者中,420名被纳入最终分析。在各个中心,每位患者的药物中位数为3至5种,多药联用率为23%至41%。在规定药物中,阿片类激动剂治疗药物和精神药物是所有机构开具的主要类别。非阿片类镇痛药是5个机构中4个机构开具的最主要“按需”药物。确定的主要潜在药物治疗问题是药物相互作用导致镇静作用增强。
本研究中的所有机构均存在多药联用情况,3个机构中超过25%的患者受到影响。开具的主要药物与文献中确定的药物一致;然而,仍有优化治疗的机会。