Joffe R T, Post R M, Roy-Byrne P P, Uhde T W
Am J Psychiatry. 1985 Oct;142(10):1196-9. doi: 10.1176/ajp.142.10.1196.
The hematological effects of carbamazepine, a drug effective in the acute and prophylactic treatment of manic-depressive disorder, were assessed in 43 subjects with affective disorder. Carbamazepine was found to cause statistically significant, but clinically insubstantial, decreases in white blood cell indexes. The consistent decreases in white cell counts observed with carbamazepine should be differentiated from the extremely rare, idiosyncratic blood dyscrasias reported in the literature.
卡马西平是一种对躁郁症急性发作和预防治疗有效的药物，研究人员对43名情感障碍患者评估了其血液学效应。结果发现，卡马西平会使白细胞指数出现具有统计学意义但临床上并不显著的下降。卡马西平所观察到的白细胞计数持续下降应与文献中报道的极为罕见的特异质性血液系统疾病相区分。
