Joffe R T, Post R M, Uhde T W
Psychol Med. 1986 May;16(2):331-5. doi: 10.1017/s0033291700009144.
The effects on serum electrolytes of carbamazepine, an acute and prophylactic treatment for manic-depressive illness, were assessed in subjects with primary affective disorder. Carbamazepine caused statistically significant, but clinically insubstantial, reductions in serum sodium and calcium, but not in the other electrolytes measured. Decreases in serum sodium and calcium were not related to carbamazepine dose, blood levels, or the degree of clinical improvement. The theoretical implications of these findings are discussed.
在原发性情感障碍患者中评估了卡马西平（一种用于治疗躁郁症的急性和预防性药物）对血清电解质的影响。卡马西平导致血清钠和钙出现具有统计学意义但临床上无实质影响的降低，而对所测量的其他电解质无此影响。血清钠和钙的降低与卡马西平剂量、血药浓度或临床改善程度无关。讨论了这些发现的理论意义。
