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Commentary: Triclabendazole induces pyroptosis by activating caspase-3 to cleave GSDME in breast cancer cells.

作者信息

Guo Jie, Peng Wen-Long, Li Chen-Guang, Wang Yu-Long

机构信息

Department of Rehabilitation Medicine, Shenzhen Second People's Hospital, Shenzhen, China.

Pain Department of Shenzhen Nanshan People's Hospital, Shenzhen, China.

出版信息

Front Pharmacol. 2025 Apr 30;16:1583920. doi: 10.3389/fphar.2025.1583920. eCollection 2025.

DOI:10.3389/fphar.2025.1583920
PMID:40371335
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12075937/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48b2/12075937/090a97c35bc6/fphar-16-1583920-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48b2/12075937/4eabe957a1a1/fphar-16-1583920-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48b2/12075937/090a97c35bc6/fphar-16-1583920-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48b2/12075937/4eabe957a1a1/fphar-16-1583920-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48b2/12075937/090a97c35bc6/fphar-16-1583920-g002.jpg

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本文引用的文献

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Int J Biol Macromol. 2023 Mar 15;231:123310. doi: 10.1016/j.ijbiomac.2023.123310. Epub 2023 Jan 20.
2
Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research.针对癌症治疗的细胞死亡途径：细胞坏死、细胞焦亡、铁死亡和铜死亡研究的新进展。
J Hematol Oncol. 2022 Dec 8;15(1):174. doi: 10.1186/s13045-022-01392-3.
3
Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells.
三氯苯达唑通过激活半胱天冬酶-3裂解乳腺癌细胞中的Gasdermin E诱导细胞焦亡。
Front Pharmacol. 2021 Jul 8;12:670081. doi: 10.3389/fphar.2021.670081. eCollection 2021.
4
The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer.半胱天冬酶-3/颗粒酶丝氨酸蛋白酶D信号通路作为癌症中细胞凋亡和细胞焦亡之间的转换开关。
Cell Death Discov. 2020 Oct 28;6:112. doi: 10.1038/s41420-020-00349-0. eCollection 2020.
5
Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells.半胱氨酸天冬氨酸蛋白酶 3 介导 GSDME 切割在结肠癌细胞洛铂诱导的细胞焦亡中的作用。
Cell Death Dis. 2019 Feb 25;10(3):193. doi: 10.1038/s41419-019-1441-4.
6
Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation.化疗药物紫杉醇和顺铂通过 caspase-3/GSDME 激活差异诱导 A549 肺癌细胞发生细胞焦亡。
Apoptosis. 2019 Apr;24(3-4):312-325. doi: 10.1007/s10495-019-01515-1.
7
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.化疗药物通过半胱天冬酶-3 对 gasdermin 的切割诱导细胞焦亡。
Nature. 2017 Jul 6;547(7661):99-103. doi: 10.1038/nature22393. Epub 2017 May 1.
8
Cell-in-Cell Death Is Not Restricted by Caspase-3 Deficiency in MCF-7 Cells.细胞内细胞死亡不受MCF-7细胞中半胱天冬酶-3缺乏的限制。
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