系统性红斑狼疮患者感染新冠病毒后的心理状况：一项前瞻性观察研究。

Post-COVID-19 psychological condition in systemic lupus erythematosus patients: a prospective observational study.

作者信息

Wu Jingyi, Zhang Lijuan, Zhou Zhuochao, Wu Yaping, Sun Yue, Wang Fan, Teng Jialin, Liu Honglei, Cheng Xiaobing, Su Yutong, Shi Hui, Hu Qiongyi, Meng Jianfen, Chi Huihui, Jia Jinchao, Liu Tingting, Wang Mengyan, Li Jian, Zhong Huiping, Yang Chengde, Ye Junna

机构信息

Department of Rheumatology and Immunology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Department of Nursing, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

出版信息

Clin Exp Rheumatol. 2025 May 8. doi: 10.55563/clinexprheumatol/2uqnsn.

DOI:10.55563/clinexprheumatol/2uqnsn

PMID:40371552

Abstract

OBJECTIVES

To assess the post-COVID-19 psychological condition of systemic lupus erythematosus (SLE) patients and the internal relationship between psychiatric symptoms.

METHODS

A total of 619 SLE patients were included in this observational study, with 493 diagnosed with COVID-19 and 126 remaining uninfected. Visual analogue scale (VAS), Multi-dimensional Fatigue Inventory (MFI), Patient Health Questionnaire-9 (PHQ-9), and Pittsburgh Sleep Quality Index (PSQI) were utilised to assess pain, exhaustion, depression, and sleep quality, respectively. Network analysis found the core symptoms and bridge symptoms. Logistic regression was utilised to assess the impact of COVID-19 symptoms on later psychiatric symptoms.

RESULTS

COVID-19 infected SLE patients had higher levels of pain, 'General Fatigue' (GF), PHQ-9, and PSQI ratings compared to others (p=0.006, 0.027, 0.003, and 0.049, respectively). The infected SLE patients' network of depression, fatigue, and sleep issues identified GF and 'Feeling down, hopeless' (PHQ2) as core symptoms with the greatest expected influence of 1.20. The symptoms 'Trouble sleeping' (PHQ3), GF and 'Daytime dysfunction' (DD) were bridge symptoms with greatest bridge expected influence of 0.72, 0.56 and 0.53, respectively. COVID-19 symptoms such as shortness of breath, weakness, and joint discomfort were linked to post-COVID-19 psychological condition.

CONCLUSIONS

Our study demonstrated a worse long-term mental status in COVID-19 infected SLE patients. Early screening and specific therapies might help prevent mental issues in SLE patients.

摘要

目的

评估新冠病毒病后系统性红斑狼疮（SLE）患者的心理状况以及精神症状之间的内在关系。

方法

本观察性研究共纳入619例SLE患者，其中493例被诊断为新冠病毒病，126例未感染。分别采用视觉模拟量表（VAS）、多维疲劳量表（MFI）、患者健康问卷-9（PHQ-9）和匹兹堡睡眠质量指数（PSQI）评估疼痛、疲惫、抑郁和睡眠质量。网络分析找出核心症状和桥梁症状。采用逻辑回归评估新冠病毒病症状对后期精神症状的影响。

结果

与其他患者相比，感染新冠病毒病的SLE患者的疼痛、“总体疲劳”（GF）、PHQ-9评分和PSQI评分更高（分别为p = 0.006、0.027、0.003和0.049）。感染新冠病毒病的SLE患者的抑郁、疲劳和睡眠问题网络确定GF和“情绪低落、绝望”（PHQ2）为核心症状，预期最大影响为1.20。症状“睡眠困难”（PHQ3）、GF和“日间功能障碍”（DD）为桥梁症状，预期最大桥梁影响分别为0.72、0.56和0.53。新冠病毒病症状如呼吸急促、虚弱和关节不适与新冠病毒病后心理状况有关。