Xie Peichen, Wang Yiqin, Xu Xinghao, Tan Li, Guo Xingdi, Xu Ziqi, Ye Rong, Zhang Manhuai, Zhuang Xiaodong, Li Zhijian, Chen Wei, Liao Xinxue, Li Bin
Department of Nephrology The First Affiliated Hospital of Sun Yat-sen University Guangzhou People's Republic of China.
NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology Guangzhou People's Republic of China.
J Am Heart Assoc. 2025 May 20;14(10):e038445. doi: 10.1161/JAHA.124.038445. Epub 2025 May 15.
Cardiovascular-kidney-metabolic (CKM) syndrome is an emerging clinical entity emphasizing the need for a holistic approach to patient care. The relationship between CKM syndrome and cognitive decline or dementia remains undetermined.
A total of 10 426 participants in the ARIC (Atherosclerosis Risk in Communities) study, classified into 4 CKM risk categories at baseline (visit 2: 1990-1992): low risk (≤5%), borderline risk (5%-7.4%), intermediate risk (7.5%-19.9%), and high risk (≥20%), were used to investigate the associations between CKM risk and cognitive decline or dementia using regression analysis.
Elevated CKM risk level is significantly associated with increased risks of cognitive decline and dementia incidence. Each 1-unit increase in CKM risk level is linked to a 6% higher risk of dementia progression in the fully adjusted model.
These findings highlight a strong association between CKM syndrome and cognitive decline or incident dementia, underscoring the importance of early interventions.
心血管-肾脏-代谢（CKM）综合征是一种新出现的临床实体，强调对患者护理采取整体方法的必要性。CKM综合征与认知衰退或痴呆之间的关系仍未确定。
社区动脉粥样硬化风险（ARIC）研究中的10426名参与者，在基线时（第2次访视：1990 - 1992年）被分为4个CKM风险类别：低风险（≤5%）、边缘风险（5% - 7.4%）、中度风险（7.5% - 19.9%）和高风险（≥20%），使用回归分析来研究CKM风险与认知衰退或痴呆之间的关联。
CKM风险水平升高与认知衰退风险增加和痴呆发病率显著相关。在完全调整模型中，CKM风险水平每增加1个单位，痴呆进展风险就会高出6%。
这些发现凸显了CKM综合征与认知衰退或新发痴呆之间的紧密关联，强调了早期干预的重要性。
