Vassalotti Joseph A, Francis Anna, Dos Santos Augusto Cesar Soares, Correa-Rotter Ricardo, Abdellatif Dina, Hsiao Li-Li, Roumeliotis Stefanos, Haris Agnes, Kumaraswami Latha A, Lui Siu-Fai, Balducci Alessandro, Liakopoulos Vassilios
Mount Sinai Hospital, Department of Medicine-Renal Medicine, New York, New York, USA; National Kidney Foundation, Inc., New York, New York, USA
co-first authors
Nephrol Ther. 2025 May 15;21(2):65-72. doi: 10.1684/ndt.2025.120.
Early detection of kidney disease can protect kidney health, prevent kidney disease progression and related complications, reduce the risk of cardiovascular disease, and decrease mortality. We must ask, “Are your kidneys ok?” by using serum creatinine to estimate kidney function and urine albumin to assess kidney and endothelial damage. Evaluation of causes and risk factors for chronic kidney disease (CKD) includes testing for diabetes, as well as measuring blood pressure and body mass index. This World Kidney Day we assert that case-finding in high-risk populations – or even population-level screening – can significantly reduce the global burden of kidney disease. Early-stage CKD is asymptomatic and simple to test for. Recent paradigm-shifting CKD treatments, such as sodium-glucose cotransporter-2 inhibitors, dramatically improve outcomes and favor the cost-benefit analysis for screening or case-finding programs. Despite this, numerous barriers exist, including resource allocation, health care funding, infrastructure, and both health care professionals’ and the public’s awareness of kidney disease. Coordinated efforts by major kidney-focused non-governmental organizations to prioritize kidney health within government agendas and align early detection efforts with other current programs will maximize efficiencies.
早期发现肾脏疾病可以保护肾脏健康,预防肾脏疾病进展及相关并发症,降低心血管疾病风险,并降低死亡率。我们必须通过检测血清肌酐以评估肾功能,检测尿白蛋白以评估肾脏和内皮损伤,来询问“你的肾脏还好吗?”。对慢性肾脏病(CKD)病因和风险因素的评估包括检测糖尿病,以及测量血压和体重指数。在今年的世界肾脏日,我们断言,在高危人群中进行病例发现——甚至是在人群层面进行筛查——可以显著减轻全球肾脏疾病负担。早期CKD没有症状,检测也很简单。近期如钠-葡萄糖协同转运蛋白2抑制剂等改变CKD治疗模式的疗法,显著改善了治疗效果,有利于筛查或病例发现项目的成本效益分析。尽管如此,仍存在许多障碍,包括资源分配、医疗保健资金、基础设施,以及医疗保健专业人员和公众对肾脏疾病的认识。主要的肾脏相关非政府组织应协同努力,将肾脏健康纳入政府议程的优先事项,并使早期发现工作与其他现有项目保持一致,以实现效率最大化。