好事成三：不同的秀丽隐杆线虫基底膜利用新型IV型胶原蛋白三聚体。
Good things come in threes: Distinct C. elegans basement membranes utilize novel collagen IV trimers.
作者信息
Peebles K Elkie, Page-McCaw Andrea
机构信息
Department of Cell and Developmental Biology, Center for Matrix Biology, Program in Developmental Biology, Vanderbilt University, Nashville, TN, USA.
出版信息
J Cell Biol. 2025 Jun 2;224(6). doi: 10.1083/jcb.202503175. Epub 2025 May 15.
Abstract
The highly conserved basement membrane protein collagen IV is stereotypically composed of two α1 subunits and one α2 subunit. In this issue, Srinivasan et al. (https://doi.org/10.1083/jcb.202412118) show that specific C. elegans basement membranes include collagen IV trimers with other compositions, suggesting a new diversity.
摘要
高度保守的基底膜蛋白IV型胶原蛋白通常由两个α1亚基和一个α2亚基组成。在本期中，Srinivasan等人（https://doi.org/10.1083/jcb.202412118）表明，秀丽隐杆线虫的特定基底膜包含具有其他组成的IV型胶原蛋白三聚体，这表明了一种新的多样性。
相似文献
1
Good things come in threes: Distinct C. elegans basement membranes utilize novel collagen IV trimers.
J Cell Biol. 2025 Jun 2;224(6). doi: 10.1083/jcb.202503175. Epub 2025 May 15.
2
A collagen IV fluorophore knock-in toolkit reveals trimer diversity in C. elegans basement membranes.
J Cell Biol. 2025 Jun 2;224(6). doi: 10.1083/jcb.202412118. Epub 2025 Mar 18.
3
Genetic interaction between Caenorhabditis elegans teneurin ten-1 and prolyl 4-hydroxylase phy-1 and their function in collagen IV-mediated basement membrane integrity during late elongation of the embryo.
Mol Biol Cell. 2011 Sep;22(18):3331-43. doi: 10.1091/mbc.E10-10-0853. Epub 2011 Jul 27.
4
Genetic Suppression of Basement Membrane Defects in by Gain of Function in Extracellular Matrix and Cell-Matrix Attachment Genes.
Genetics. 2018 Apr;208(4):1499-1512. doi: 10.1534/genetics.118.300731. Epub 2018 Feb 12.
5
α-Integrins dictate distinct modes of type IV collagen recruitment to basement membranes.
J Cell Biol. 2019 Sep 2;218(9):3098-3116. doi: 10.1083/jcb.201903124. Epub 2019 Aug 6.
6
Basement membrane type IV collagen molecules in the choroid plexus, pia mater and capillaries in the mouse brain.
Arch Histol Cytol. 2002 Jun;65(2):133-43. doi: 10.1679/aohc.65.133.
7
Type IV collagen is detectable in most, but not all, basement membranes of Caenorhabditis elegans and assembles on tissues that do not express it.
J Cell Biol. 1997 Jun 2;137(5):1171-83. doi: 10.1083/jcb.137.5.1171.
8
Genetic interactions among ADAMTS metalloproteases and basement membrane molecules in cell migration in Caenorhabditis elegans.
PLoS One. 2020 Dec 2;15(12):e0240571. doi: 10.1371/journal.pone.0240571. eCollection 2020.
9
Atg9 is a conserved regulator of lysosome repair.
J Cell Biol. 2025 Jul 7;224(7). doi: 10.1083/jcb.202504129. Epub 2025 May 13.
10
The Role of Tissue Inhibitors of Metalloproteinases in Organ Development and Regulation of ADAMTS Family Metalloproteinases in .
Genetics. 2019 Jun;212(2):523-535. doi: 10.1534/genetics.119.301795. Epub 2019 Apr 16.
本文引用的文献
1
Skeletal pathology in mouse models of Gould syndrome is partially alleviated by genetically reducing TGFβ signaling.
Matrix Biol. 2024 Nov;133:1-13. doi: 10.1016/j.matbio.2024.07.005. Epub 2024 Aug 6.
2
Comprehensive Endogenous Tagging of Basement Membrane Components Reveals Dynamic Movement within the Matrix Scaffolding.
Dev Cell. 2020 Jul 6;54(1):60-74.e7. doi: 10.1016/j.devcel.2020.05.022. Epub 2020 Jun 24.
3
Type IV Collagens and Basement Membrane Diseases: Cell Biology and Pathogenic Mechanisms.
Curr Top Membr. 2015;76:61-116. doi: 10.1016/bs.ctm.2015.09.002. Epub 2015 Oct 20.
4
Mammalian collagen IV.
Microsc Res Tech. 2008 May;71(5):357-70. doi: 10.1002/jemt.20564.
5
viking: identification and characterization of a second type IV collagen in Drosophila.
Gene. 1997 Oct 1;198(1-2):17-25. doi: 10.1016/s0378-1119(97)00274-6.
6
The two Caenorhabditis elegans basement membrane (type IV) collagen genes are located on separate chromosomes.
J Biol Chem. 1989 Oct 15;264(29):17574-82.
Zotero 插件