Wang Ruoxi, Baehrecke Eric H
Department of Neuroscience, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
J Cell Biol. 2025 Jul 7;224(7). doi: 10.1083/jcb.202504129. Epub 2025 May 13.
The ATG9 transmembrane protein scrambles lipids to regulate phagophore formation during autophagy. Two recent studies from Peng et al. (https://doi.org/10.1083/jcb.202411092) and De Tito et al. (https://doi.org/10.1101/2024.07.23.604321) identify ATG9 as a conserved regulator of lysosome repair in Caenorhabditis elegans and human cells, but differences in repair mechanisms exist between these taxa.
