Hanada T, Abe T, Takita H
Am J Pediatr Hematol Oncol. 1985 Spring;7(1):3-8.
Six children (1 month to 5 years old) with DIC were treated with bolus injection of AT-III concentrates and/or continuous heparin infusion. In one case, when AT-III concentrates were administered without heparin, the platelet count was normalized in accordance with a rise in the plasma AT-III level. In the other children, who were treated with both AT-III concentrates and heparin, most of the abnormalities in coagulation studies were normalized within 5 days in four of five cases. These findings suggest that the administration of AT-III concentrates may significantly enhance the therapeutic efficacy of heparin, and that the use of AT-III concentrates with heparin is a safe and effective regimen for the treatment of childhood DIC.
六名患有弥散性血管内凝血（DIC）的儿童（年龄从1个月至5岁）接受了静脉推注抗凝血酶III（AT-III）浓缩物和/或持续肝素输注治疗。在一个病例中，在未使用肝素的情况下给予AT-III浓缩物，血小板计数随着血浆AT-III水平的升高而恢复正常。在其他同时接受AT-III浓缩物和肝素治疗的儿童中，五例中有四例凝血研究中的大多数异常在5天内恢复正常。这些发现表明，给予AT-III浓缩物可能会显著增强肝素的治疗效果，并且将AT-III浓缩物与肝素联合使用是治疗儿童DIC的一种安全有效的方案。
