在一个全国性队列（ABCMML）和一个国际队列（cBioPortal）中，NRAS突变的慢性粒单核细胞白血病患者的特征。

Characteristics of NRAS-mutated patients with chronic myelomonocytic leukemia in a national (ABCMML) and an international cohort (cBioPortal).

作者信息

Qian Alexandra, Geissler Klaus

机构信息

Medical School, Sigmund Freud University, Sigmund Freud Platz 3, 1020, Vienna, Austria.

Karl Landsteiner Institut für hämatoonkologische Forschung, St. Pölten, Austria.

出版信息

Wien Med Wochenschr. 2025 May 15. doi: 10.1007/s10354-025-01080-0.

DOI:10.1007/s10354-025-01080-0

PMID:40372530

Abstract

Big data from large international cooperations allow proving consistency of findings in national patient cohorts. We compared features in NRAS-mutated patients of the Austrian biodatabase for chronic myelomonocytic leukemia (ABCMML) with the chronic myelomonocytic leukemia (CMML) cohort documented in cBioPortal. It is consistently demonstrated in both CMML cohorts that NRAS mutations are associated with shorter overall survival, acute myeloid leukemia-free survival, increased white blood cell count, decreased platelet values and the presence of blast cells in peripheral blood. Hemoglobin values did not differ between patients with or without NRAS mutations in either cohort. Validation of data in CMML patients using two independent cohorts, ensures the quality standards for clinical decision making.

摘要

来自大型国际合作的大数据能够证实各国患者队列研究结果的一致性。我们将奥地利慢性粒单核细胞白血病生物数据库（ABCMML）中NRAS突变患者的特征与cBioPortal记录的慢性粒单核细胞白血病（CMML）队列进行了比较。在两个CMML队列中均一致表明，NRAS突变与总生存期缩短、无急性髓系白血病生存期缩短、白细胞计数增加、血小板值降低以及外周血中原始细胞的存在有关。在任一队列中，有或无NRAS突变的患者之间血红蛋白值并无差异。使用两个独立队列对CMML患者的数据进行验证，确保了临床决策的质量标准。