Economopoulos T C, Papayannis A G, Stathakis N E, Arapakis G, Gardikas C
Acta Haematol. 1977;57(5):266-71. doi: 10.1159/000207890.
Several platelet function tests were performed on 31 patients undergoing major operations, who recieved prophylactically small subcutaneous doses of heparin. A group of 15 similar patients without heparin served as controls. It was found that postoperatively in both groups (a) the platelet retention in glass bead column was significantly increased (p less than 0.001), (b) the platelet aggregation by ADP 1 micronM was slightly increased, (c) the collagen-induced aggregation, ADP release and the bleeding time remained unchanged and (d) the platelet counts decreased in the first 2 postoperative days and increased thereafter. There was no difference between patients on heparin and controls.
对31例接受大手术且预防性皮下注射小剂量肝素的患者进行了多项血小板功能测试。选取15例未使用肝素的类似患者作为对照组。结果发现，两组患者术后：(a)玻璃珠柱中的血小板滞留率显著增加（p<0.001），(b)1微摩尔/升二磷酸腺苷（ADP）诱导的血小板聚集略有增加，(c)胶原诱导的聚集、ADP释放和出血时间保持不变，(d)术后前两天血小板计数下降，此后上升。使用肝素的患者与对照组之间无差异。
