Gurbanov Vusal, Öztürk Ayla, Doğruel Fatma, Saraçoğlu Hatice, Yazıcı Cevat
Department of Periodontology, School of Dentistry, Erciyes University, Kayseri, Türkiye.
Department of Periodontology, School of Dentistry, Ankara University, Ankara, Türkiye.
J Clin Periodontol. 2025 Aug;52(8):1115-1124. doi: 10.1111/jcpe.14175. Epub 2025 May 15.
To investigate whether restoring serum vitamin D levels in a population requiring supplementation affects matrix metalloproteinase-9 (MMP-9) levels in the gingival crevicular fluid (GCF) of individuals with periodontal health, gingivitis and periodontitis.
This prospective cohort study enrolled 101 participants with vitamin D deficiency, including those with periodontitis (34) and gingivitis (34) and healthy individuals (33). The periodontal status was evaluated using radiographic and clinical assessments of probing depth, clinical attachment loss, gingival index and plaque index. The analysis of MMP-9 levels in the GCF collected from the same dental sites was performed at baseline and 1 month post supplementation.
After 1 month of vitamin D supplementation, a significant decrease in GCF MMP-9 levels was observed across all groups, with the most notable reduction observed in the periodontitis group. The healthy group exhibited the highest percentage reduction at 47%. Linear regression analysis confirmed that changes in vitamin D levels and pocket depth influenced MMP-9 alterations in the GCF.
Restoration of vitamin D levels in vitamin D-deficient patients to the recommended average level (30 ng/mL), according to established guidelines, led to decreased MMP-9 levels in individuals with different periodontal statuses (healthy, gingivitis or periodontitis), potentially mitigating periodontal risks.
研究在需要补充维生素D的人群中恢复血清维生素D水平是否会影响牙周健康、牙龈炎和牙周炎患者龈沟液（GCF）中基质金属蛋白酶-9（MMP-9）的水平。
这项前瞻性队列研究纳入了101名维生素D缺乏的参与者，包括牙周炎患者（34名）、牙龈炎患者（34名）和健康个体（33名）。使用影像学和临床评估探诊深度、临床附着丧失、牙龈指数和菌斑指数来评估牙周状况。在基线和补充1个月后，对从相同牙位采集的GCF中的MMP-9水平进行分析。
补充维生素D 1个月后，所有组的GCF中MMP-9水平均显著下降，其中牙周炎组下降最为明显。健康组的下降百分比最高，为47%。线性回归分析证实，维生素D水平和牙周袋深度的变化影响了GCF中MMP-9的改变。
根据既定指南，将维生素D缺乏患者的维生素D水平恢复到推荐的平均水平（30 ng/mL），可使不同牙周状况（健康、牙龈炎或牙周炎）个体的MMP-9水平降低，可能减轻牙周风险。
