Lewis J E, Richards W, Church J A, Haftel A, Keens T G
Ann Allergy. 1985 Sep;55(3):472-5.
Ninety-one children with acute asthma were studied to determine the extent of incremental improvement in pulmonary function afforded by successive doses of subcutaneous epinephrine, and by a bronchodilator aerosol in those patients refractory to epinephrine. A significant proportion of patients (69%), as expected, responded to the first injection. Among those who did not respond to the first injection a significant proportion (30%) responded to the second injection. Markedly fewer patients responded to subsequent bronchodilator treatments, including aerosols, if they did not improve significantly after the first two treatments. Patients with higher initial peak flow rates (PEFR) generally required fewer epinephrine injections, and achieved higher maximal PEFR than those with lower initial PEFR. Most asthmatic patients who required hospital admission had lower initial peak flow rates, were less responsive to epinephrine injections, and achieved lower maximal rates than those who could be discharged home.
对91名急性哮喘患儿进行了研究，以确定皮下注射肾上腺素连续剂量以及对肾上腺素难治的患者使用支气管扩张气雾剂后肺功能的递增改善程度。正如预期的那样，相当一部分患者（69%）对首次注射有反应。在那些对首次注射无反应的患者中，相当一部分（30%）对第二次注射有反应。如果在前两次治疗后没有显著改善，那么对随后包括气雾剂在内的支气管扩张剂治疗有反应的患者明显减少。初始峰值流速（PEFR）较高的患者通常需要较少的肾上腺素注射，并且比初始PEFR较低的患者达到更高的最大PEFR。大多数需要住院治疗的哮喘患者初始峰值流速较低，对肾上腺素注射反应较小，并且比可以出院回家的患者达到的最大流速更低。
