Jiang Ming, Li Zhuoneng, Qin Xu, Chen Lili, Zhu Guangxun
Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Am J Chin Med. 2025;53(3):771-801. doi: 10.1142/S0192415X25500296.
AMP-activated protein kinase (AMPK) is a ubiquitous sensor of cellular energy and nutrient status in eukaryotic cells. It serves an essential function in the modulation of energy balance and metabolism homeostasis through its regulation of carbohydrate metabolism, lipid metabolism and protein metabolism. The dysregulation of AMPK is closely related to a series of systemic diseases, affecting multiple organs and tissues. Baicalin is a natural compound derived from the dry raw root of , and it has been found to exhibit several potential pharmacological actions. These include hepatoprotective effects, anti-inflammation effects and anti-tumor effects. These biological activities are related to the regulatory effect of baicalin on the host metabolism, which is closely associated with AMPK modulation. In this review, we provide an overview of the regulatory effect of baicalin on AMPK and its upstream and downstream signaling pathways. The pharmacological properties and underlying mechanism of baicalin for regulating AMPK were summarized with regards to four aspects: regulatory effect of baicalin on AMPK in lipid metabolism and glucose metabolism, regulatory effect of baicalin on AMPK in its pharmacological effect of anti-tumor and anti-inflammation. As a natural compound, baicalin has the potential for the management of certain AMPK-related diseases.
AMP激活的蛋白激酶（AMPK）是真核细胞中普遍存在的细胞能量和营养状态传感器。它通过调节碳水化合物代谢、脂质代谢和蛋白质代谢，在调节能量平衡和代谢稳态方面发挥着重要作用。AMPK的失调与一系列全身性疾病密切相关，影响多个器官和组织。黄芩苷是一种从黄芩干燥根中提取的天然化合物，已发现它具有多种潜在的药理作用。这些作用包括肝脏保护作用、抗炎作用和抗肿瘤作用。这些生物学活性与黄芩苷对宿主代谢的调节作用有关，而这与AMPK的调节密切相关。在本综述中，我们概述了黄芩苷对AMPK及其上下游信号通路的调节作用。从四个方面总结了黄芩苷调节AMPK的药理特性和潜在机制：黄芩苷在脂质代谢和葡萄糖代谢中对AMPK的调节作用、黄芩苷在抗肿瘤和抗炎药理作用中对AMPK的调节作用。作为一种天然化合物，黄芩苷在治疗某些与AMPK相关疾病方面具有潜力。
