Lu Qirong, Zhang Xue, Zhang Jie, Wang Xinyue, Wen Defeng, Guo Pu, Xiong Jianglin, Qiu Yinsheng
Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China.
Wuhan Engineering and Technology Research Center of Animal Disease-Resistant Nutrition, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China.
Animals (Basel). 2025 Aug 8;15(16):2325. doi: 10.3390/ani15162325.
Aflatoxin B1 (AFB1) is a highly toxic secondary metabolite produced by species. Its extensive contamination of animal feed and human food poses significant health hazards to livestock and humans, with hepatotoxicity being a primary concern. This study investigated the protective effect of baicalin on AFB1-induced liver injury in ducklings. In the first experiment, ducklings were administered AFB1 at doses of 0, 6, 12, or 24 μg/kg body weight/day for 7 days to identify the optimal concentration for establishing a model of AFB1-induced growth performance and liver injury. Administration of AFB1, particularly at the higher doses (12 and 24 μg/kg body weight/day), significantly reduced growth performance and induced structural and functional liver injury ( < 0.05). In a second experiment, ducklings were administered AFB1 (12 μg/kg body weight/day) with or without baicalin (25-100 mg/kg body weight/day) for 7 days. Dietary baicalin significantly increased the serum albumin level; reduced the serum alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase levels; improved growth performance; and ameliorated structural and functional liver injury in ducklings exposed to AFB1 ( < 0.05). The results indicate that dietary baicalin alleviates AFB1-induced liver injury and growth performance decline in ducklings. Hence, baicalin could serve as a potential feed additive to reduce the harmful effects of AFB1 in the poultry breeding industry.
黄曲霉毒素B1（AFB1）是由某些物种产生的一种剧毒次生代谢产物。它对动物饲料和人类食物的广泛污染对家畜和人类构成了重大健康危害，肝毒性是主要关注点。本研究调查了黄芩苷对AFB1诱导的雏鸭肝损伤的保护作用。在第一个实验中，雏鸭分别以0、6、12或24μg/千克体重/天的剂量给予AFB1，持续7天，以确定建立AFB1诱导的生长性能和肝损伤模型的最佳浓度。给予AFB1，特别是较高剂量（12和24μg/千克体重/天）时，显著降低了生长性能并诱导了肝脏的结构和功能损伤（P<0.05）。在第二个实验中，雏鸭给予AFB1（12μg/千克体重/天），同时或不同时给予黄芩苷（25 - 100毫克/千克体重/天），持续7天。日粮中的黄芩苷显著提高了血清白蛋白水平；降低了血清丙氨酸氨基转移酶、天冬氨酸氨基转移酶和γ-谷氨酰转移酶水平；改善了生长性能；并减轻了暴露于AFB1的雏鸭的肝脏结构和功能损伤（P<0.05）。结果表明，日粮中的黄芩苷可减轻AFB1诱导的雏鸭肝损伤和生长性能下降。因此，黄芩苷可作为一种潜在的饲料添加剂，以减少AFB1在家禽养殖业中的有害影响。
