靶向谷胱甘肽过氧化物酶4（GPX4）的棕榈酰化以增强抗肿瘤免疫力。

Targeting GPX4 palmitoylation to boost antitumor immunity.

作者信息

Hwang Daehee, Henry Whitney S

机构信息

Department of Biology, Massachusetts Institute of Technology, Koch Institute for Integrative Cancer Research, Cambridge, MA, USA.

出版信息

Trends Cancer. 2025 Jun;11(6):491-492. doi: 10.1016/j.trecan.2025.05.001. Epub 2025 May 14.

DOI:10.1016/j.trecan.2025.05.001

PMID:40374398

Abstract

Despite significant milestones in cancer immunotherapy, tumor cells often escape immune surveillance. Zhou et al. revealed that the pivotal ferroptosis suppressor glutathione peroxidase 4 (GPX4) can undergo palmitoylation by zDHHC8, enhancing ferroptosis resistance. This study highlights the potential of targeting GPX4 palmitoylation to enhance cytotoxic T cell-mediated ferroptosis of tumor cells.

摘要

尽管癌症免疫疗法取得了重大进展，但肿瘤细胞常常逃避免疫监视。周等人发现，关键的铁死亡抑制因子谷胱甘肽过氧化物酶4（GPX4）可被zDHHC8棕榈酰化，从而增强铁死亡抗性。这项研究突出了靶向GPX4棕榈酰化以增强细胞毒性T细胞介导的肿瘤细胞铁死亡的潜力。