文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

Pinosylvin and Sanguinarine Combination to Enhance Antifungal Activity against .

作者信息

Yue Yaxuan, Liu Jing, Li Chen, Chen Fengfeng, Yang Cheng, Zhao Bingtian

机构信息

Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, P.R. China.

School of Chemistry, Biology and Environment, Yuxi Normal University, Yuxi 653100, P.R. China.

出版信息

J Microbiol Biotechnol. 2025 May 15;35:e2412055. doi: 10.4014/jmb.2412.12055.

DOI:10.4014/jmb.2412.12055
PMID:40374536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12099613/
Abstract

is one of the major sources of fungal infections that can lead to life-threatening systemic infections. However, effective control of remains a great challenge. Herein, this study aimed at investigating the antifungal effect of a combination of two natural compounds, pinosylvin (PIN) and sanguinarine (SAN), against . In order to investigate the antifungal effect and mechanism of the combination of PIN and SAN, antimicrobial assay, time-kill assay, biofilm formation assay, cell membrane integrity assay, and reactive oxygen species (ROS) assay were performed. The results showed that the combination of PIN and SAN was more effective against than PIN or SAN alone. PIN and SAN could jointly inhibit biofilm formation and thus attenuate adhesion and colonization ability. PIN mainly targeting the cell membrane while SAN mainly inducing the cell to produce large amounts of ROS. Besides, PIN promoted the entry of SAN into . Finally, the hemolysis experiment demonstrated that the combination of PIN and SAN is biocompatible. Taken together, the combination of PIN and SAN enhanced the antifungal effect against , which has a broad application prospect in the control of .

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c56d/12099613/54c4324de24f/jmb-35-e2412055-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c56d/12099613/5c4ffcd82274/jmb-35-e2412055-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c56d/12099613/dae9b4e54731/jmb-35-e2412055-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c56d/12099613/39aafbb9075c/jmb-35-e2412055-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c56d/12099613/7f82de8bec3d/jmb-35-e2412055-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c56d/12099613/4a9e3154c69e/jmb-35-e2412055-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c56d/12099613/1f5072d67d9b/jmb-35-e2412055-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c56d/12099613/77dd2164d4e2/jmb-35-e2412055-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c56d/12099613/54c4324de24f/jmb-35-e2412055-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c56d/12099613/5c4ffcd82274/jmb-35-e2412055-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c56d/12099613/dae9b4e54731/jmb-35-e2412055-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c56d/12099613/39aafbb9075c/jmb-35-e2412055-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c56d/12099613/7f82de8bec3d/jmb-35-e2412055-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c56d/12099613/4a9e3154c69e/jmb-35-e2412055-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c56d/12099613/1f5072d67d9b/jmb-35-e2412055-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c56d/12099613/77dd2164d4e2/jmb-35-e2412055-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c56d/12099613/54c4324de24f/jmb-35-e2412055-f8.jpg

相似文献

[1]
Pinosylvin and Sanguinarine Combination to Enhance Antifungal Activity against .

J Microbiol Biotechnol. 2025-5-15

[2]
Activity of Sanguinarine against Candida albicans Biofilms.

Antimicrob Agents Chemother. 2017-4-24

[3]
Anti-microbial and anti-biofilm activities of combined chelerythrine-sanguinarine and mode of action against Candida albicans and Cryptococcus neoformans in vitro.

Colloids Surf B Biointerfaces. 2020-7

[4]
Thymus vulgaris essential oil and thymol inhibit biofilms and interact synergistically with antifungal drugs against drug resistant strains of Candida albicans and Candida tropicalis.

J Mycol Med. 2019-11-7

[5]
A novel use for an old drug: resistance reversal in by combining dihydroartemisinin with fluconazole.

Future Microbiol. 2021-5

[6]
and activity of chelerythrine against and underlying mechanisms.

Future Microbiol. 2020-1-29

[7]
Antifungal effects and potential mechanisms of lonidamine in combination with fluconazole against .

Expert Rev Anti Infect Ther. 2021-1

[8]
Fangchinoline inhibits growth and biofilm of Candida albicans by inducing ROS overproduction.

J Cell Mol Med. 2024-5

[9]
Inhibitory effects and mode of antifungal action of isobavachalcone on Candida albicans growth and virulence factors.

Biomed Pharmacother. 2024-10

[10]
Antibiofilm activity of certain phytocompounds and their synergy with fluconazole against Candida albicans biofilms.

J Antimicrob Chemother. 2011-12-13

本文引用的文献

[1]
Most azole resistance mutations in the Candida albicans drug target confer cross-resistance without intrinsic fitness cost.

Nat Microbiol. 2024-11

[2]
Activity and safety evaluation of natural preservatives.

Food Res Int. 2024-8

[3]
Fangchinoline inhibits growth and biofilm of Candida albicans by inducing ROS overproduction.

J Cell Mol Med. 2024-5

[4]
L essential oil as promising source of bioactive compounds, antioxidant, antimicrobial activities and predictions.

Heliyon. 2024-4-16

[5]
Bioactivity and mechanism of action of sanguinarine and its derivatives in the past 10 years.

Biomed Pharmacother. 2024-4

[6]
Natural Compounds with Antifungal Properties against and Identification of Hinokitiol as a Promising Antifungal Drug.

Antibiotics (Basel). 2023-11-8

[7]
Comparative genomics of infective Saccharomyces cerevisiae strains reveals their food origin.

Sci Rep. 2023-6-27

[8]
Anti-Biofilm Activity of Phenyllactic Acid against Clinical Isolates of Fluconazole-Resistant .

J Fungi (Basel). 2023-3-15

[9]
From intestinal colonization to systemic infections: translocation and dissemination.

Gut Microbes. 2022

[10]
Sanguinarine synergistically potentiates aminoglycoside-mediated bacterial killing.

Microb Biotechnol. 2022-7

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索