Winn H R, Morii S, Berne R M
Ann Biomed Eng. 1985;13(3-4):321-8. doi: 10.1007/BF02584250.
We have investigated the role of adenosine, a purine nucleoside and potent vasodilator of cerebral pial vessels, during both acute (0-60 sec) and sustained (2-5 min) changes in cerebral perfusion pressure. Brain adenosine concentrations are rapidly increased within 5 sec of the onset of systemic hypotension and parallel, in a temporal fashion, the changes in pial vessel diameter and alterations in cerebral vascular resistance. During sustained hypotension, brain levels of adenosine are increased even within the autoregulatory range. These data are constant with the hypothesis that adenosine is an important metabolic factor in cerebral autoregulation.
我们研究了腺苷（一种嘌呤核苷，是脑软膜血管的强效血管扩张剂）在脑灌注压急性（0 - 60秒）和持续性（2 - 5分钟）变化过程中的作用。在系统性低血压发作的5秒内，脑腺苷浓度迅速升高，并在时间上与软膜血管直径的变化以及脑血管阻力的改变平行。在持续性低血压期间，即使在自动调节范围内，脑内腺苷水平也会升高。这些数据与腺苷是脑自动调节中重要的代谢因子这一假说相符。
