Kojom Foko Loick Pradel, Hawadak Joseph, Belle Ebanda Kedi Philippe, Pande Veena, Singh Vineeta
Parasite and Host Biology Group, ICMR-National Institute of Malaria Research, New Delhi, 110077, India.
Department of Biotechnology, Kumaun University, 263001, Bhimtal, Uttarakhand, India.
Biol Trace Elem Res. 2025 May 16. doi: 10.1007/s12011-025-04652-8.
Green nanotechnology can provide new avenues for drug and insecticide discovery. This study aimed at synthesizing and evaluating the potential of silver nanoparticles, using an innovative plant-driven synthesis approach, with the potential to be used as an endectocide. Optimized silver nanoparticles using Ceiba pentandra (CP-AgNPs) were evaluated for their hemotoxic and killing activities against the deadliest malaria parasite Plasmodium falciparum (Pf) and three mosquito species (Culex quinquefasciatus, Anopheles stephensi, and Aedes aegypti) of medical importance. Optimized CP-AgNPs were predominantly spheroidal, stable, polycrystalline, and coated with several phytochemical compounds, including terpenoids, alkaloids, and phenols. CP-AgNPs exhibited good hemocompatibility and high lethal activity on Pf 3D7 and RKL9 strains, with respective IC values of 9.71 µg/mL and 15.57 µg/mL. Likewise, LC values were < 20 µg/mL in the three mosquito species after 24-h exposure, and the CP-AgNPs were most toxic against An. stephensi (LC = 13.48 µg/mL). Green AgNPs could be an interesting tool for discovering and developing eco-friendly and effective antimalarial drugs and insecticides.
绿色纳米技术可为药物和杀虫剂的发现提供新途径。本研究旨在采用创新的植物驱动合成方法合成并评估银纳米颗粒的潜力，其有潜力用作体内驱虫剂。对使用吉贝（CP - AgNPs）优化合成的银纳米颗粒针对最致命的疟原虫恶性疟原虫（Pf）以及三种具有医学重要性的蚊虫（致倦库蚊、斯氏按蚊和埃及伊蚊）的血液毒性和杀灭活性进行了评估。优化后的CP - AgNPs主要呈球形，稳定，多晶，并包覆有多种植物化学化合物，包括萜类、生物碱和酚类。CP - AgNPs对Pf 3D7和RKL9菌株表现出良好的血液相容性和高致死活性，其IC值分别为9.71 μg/mL和15.57 μg/mL。同样，在暴露24小时后，三种蚊虫的LC值均<20 μg/mL，且CP - AgNPs对斯氏按蚊毒性最大（LC = 13.48 μg/mL）。绿色银纳米颗粒可能是发现和开发环保且有效的抗疟药物和杀虫剂的一个有趣工具。
