Chen Wenxiu, Song Wanjuan, Zhang Hanzhi, Su Xin, Chen Jingfei, Chen Jianlin
Reproductive Medicine Center, Department of Obstetrics and Gynecology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Sci Rep. 2025 May 15;15(1):16924. doi: 10.1038/s41598-025-97352-1.
Given the controversial conclusion on the relationship between serum uric acid (SUA) levels and testosterone (T) levels in adult males, the purpose of this study is to explore the association between SUA levels and T levels in adult males. We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2011 to 2016. The association was estimated using multiple linear regression model and results are presented as β with its 95% confidence intervals (95% CIs). This study enrolled 7791 males aged 18 years or older and found a negative correlation between serum uric acid levels and testosterone levels after controlling for confounding factors. Additionally, a non-linear association was observed, with an infection point of 4.4 mg/dL for serum uric acid levels. The effect sizes on the left and right sides of the inflection point were determined as 17.93 (- 3.61 to 39.48) and - 14.73 (- 18.51 to - 10.95), respectively. Elevated SUA levels were found to be linked to decreased T levels, even after controlling for confounders. Moreover, non-linear pattern in the relationship between SUA levels and T levels was also identified.
鉴于关于成年男性血清尿酸（SUA）水平与睾酮（T）水平之间关系的结论存在争议，本研究旨在探讨成年男性SUA水平与T水平之间的关联。我们利用2011年至2016年美国国家健康与营养检查调查（NHANES）的数据进行了一项横断面研究。使用多元线性回归模型估计这种关联，并将结果表示为β及其95%置信区间（95%CI）。本研究纳入了7791名18岁及以上的男性，在控制混杂因素后发现血清尿酸水平与睾酮水平呈负相关。此外，还观察到一种非线性关联，血清尿酸水平的感染点为4.4mg/dL。拐点左右两侧的效应大小分别确定为17.93（-3.61至39.48）和-14.73（-18.51至-10.95）。即使在控制混杂因素后，也发现SUA水平升高与T水平降低有关。此外，还确定了SUA水平与T水平之间的非线性关系模式。
