First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250014, China.
Department of Endocrinology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China.
Int J Clin Pract. 2023 Jul 28;2023:8215866. doi: 10.1155/2023/8215866. eCollection 2023.
Serum uric acid (SUA) was closely related to body metabolism. This study aimed to investigate the relationship between the adult weight-adjusted waist index (WWI) and SUA.
In the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2020, 6494 eligible participants aged ≥20 were included. The multivariate logistic regression model was used to test the correlation between WWI and SUA. At the same time, subgroup analysis was carried out by using multivariate logistic regression according to age, sex, and race. Then, the fitting smooth curve was applied to solve the association between WWI and SUA. Finally, the recursive algorithm was used to calculate the inflection point in the nonlinear relationship, and the two-stage piecewise linear regression model was used to analyze the relationship between WWI and SUA on both sides of the inflection point.
In all the 6494 participants, through the fully adjusted model, this study found that there was a positive correlation between WWI and SUA ( = 5.64; 95% CI: 2.62 and 8.66). In addition, this positive correlation still had certain statistical significance in the subgroup analysis stratified by sex, age, and race. Our research team found a significant positive correlation between the WWI and SUA in females, but the correlation was not significant in males. We also found a small inverted U-shaped curve between the WWI and SUA in men when we stratified the sex subgroups. The small inflection point was determined to be 11.5 cm/√ kg. In racial subgroup analysis, we also found a U-shaped relationship between the WWI and SUA in non-Hispanic White and other race/ethnicity (the inflection point was 11.08 cm/√ kg and 12.14 cm/√ kg, respectively).
This study showed that the WWI was a newly developed and new predictor of centripetal obesity independent of body weight and there was a positive correlation between the WWI and SUA.
血清尿酸（SUA）与人体代谢密切相关。本研究旨在探讨成人体重调整腰围指数（WWI）与 SUA 的关系。
在 2011 年至 2020 年的全国健康和营养检查调查（NHANES）中，纳入了 6494 名符合条件的年龄≥20 岁的参与者。使用多变量逻辑回归模型检验 WWI 与 SUA 之间的相关性。同时，根据年龄、性别和种族，使用多变量逻辑回归进行亚组分析。然后，应用拟合平滑曲线来解决 WWI 和 SUA 之间的关联。最后，使用递归算法计算非线性关系中的拐点，并用两段分段线性回归模型分析拐点两侧的 WWI 和 SUA 之间的关系。
在所有 6494 名参与者中，通过完全调整模型，本研究发现 WWI 与 SUA 呈正相关（=5.64；95%CI：2.62 至 8.66）。此外，在按性别、年龄和种族分层的亚组分析中，这种正相关仍然具有一定的统计学意义。我们的研究团队发现，女性的 WWI 和 SUA 之间存在显著的正相关，但男性之间的相关性不显著。当我们对性别亚组进行分层时，我们还发现男性的 WWI 和 SUA 之间存在一个小的倒 U 形曲线。小拐点确定为 11.5cm/√kg。在种族亚组分析中，我们还发现非西班牙裔白人和其他种族/民族的 WWI 和 SUA 之间存在 U 形关系（拐点分别为 11.08cm/√kg 和 12.14cm/√kg）。
本研究表明，WWI 是一种新开发的、独立于体重的中心性肥胖的新预测指标，与 SUA 呈正相关。
