2011 - 2016年美国国家健康与营养检查调查：成年男性血清尿酸与睾酮之间关联的探索
Exploration of the association between serum uric acid and testosterone in adult males: NHANES 2011-2016.
作者信息
Han Yingdong, Zhang Yun, Cao Yu, Yin Yue, Han Xinxin, Di Hong, Chu Xiaotian, Zeng Xuejun
机构信息
Department of General Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
出版信息
Transl Androl Urol. 2021 Jan;10(1):272-282. doi: 10.21037/tau-20-1114.
BACKGROUND
Previous studies have suggested that the possible relationship between serum uric acid (SUA) and testosterone. However, the results of previous studies are controversial and there is limited evidence examining the relationship between SUA and testosterone in a general US population of men. The objective of this study is to explore the correlation of SUA and testosterone among adult males from the US.
METHODS
Data from the National Health and Nutrition Examination Survey 2011-2016 were used, including a total of 7,796 male participants aged 18 years or older and excluding those lacking serum testosterone and uric acid data. Clinical characteristics of the participants among different SUA groups and testosterone groups are compared. Univariate and multivariate linear regression analyses were applied to evaluate the association between SUA and testosterone.
RESULTS
We found an inverse association between SUA and testosterone after fully adjusted the potential confounding factors in general US adult males. In the multivariate linear regression analysis, we found that increasing age (estimate testosterone percent difference: -0.20% per year, P<0.01), uric acid (estimate testosterone percent difference: -4.40% per md/dL, P<0.01) and BMI (estimate testosterone percent difference: -2.86% per kg/m2, P<0.01) were associated with declining serum testosterone. This association remained significant in sensitivity analysis, while in the stratified analysis, above association was not significant in men with diabetes or aged 65 and over.
CONCLUSIONS
SUA levels might be negatively associated with serum testosterone in adult males.
背景
既往研究提示血清尿酸（SUA）与睾酮之间可能存在关联。然而，既往研究结果存在争议，且在美国普通男性人群中，研究SUA与睾酮之间关系的证据有限。本研究的目的是探讨美国成年男性中SUA与睾酮之间的相关性。
方法
使用2011 - 2016年美国国家健康与营养检查调查的数据，共纳入7796名18岁及以上的男性参与者，排除那些缺乏血清睾酮和尿酸数据的人。比较不同SUA组和睾酮组参与者的临床特征。采用单因素和多因素线性回归分析来评估SUA与睾酮之间的关联。
结果
在对美国成年男性的潜在混杂因素进行充分调整后，我们发现SUA与睾酮之间存在负相关。在多因素线性回归分析中，我们发现年龄增加（估计睾酮百分比差异：每年-0.20%，P<0.01）、尿酸（估计睾酮百分比差异：每md/dL -4.40%，P<0.01）和体重指数（估计睾酮百分比差异：每kg/m2 -2.86%，P<0.01）与血清睾酮水平下降有关。在敏感性分析中，这种关联仍然显著，而在分层分析中，上述关联在糖尿病男性或65岁及以上男性中不显著。
结论
成年男性的SUA水平可能与血清睾酮呈负相关。
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