Aitchison C S, Westfall J A, Leipold H W, Kelly P T
Am J Vet Res. 1985 Aug;46(8):1733-6.
An ultrastructural comparison was made between the motor cortex synapses of the brain of 4 adult Brown Swiss cattle with weaver syndrome and 2 healthy cattle (a Holstein steer and a Guernsey cow). Compared with the healthy cattle, the paramembranous densities at synaptic junctions of cattle with weaver syndrome had a decreased mean height of the presynaptic dense projections (P less than 0.001), had significantly smaller peak-to-peak distances (P less than 0.001), and had a significantly decreased mean thickness of the postsynaptic density (P less than 0.0001). These synaptic changes in cattle with weaver syndrome may be associated with clinical manifestations of the syndrome, such as impairment of transmitter release, instability of postsynaptic receptor sites, lesion-induced synaptic turnover from injury elsewhere in the CNS, or loss of a specific cell population of the motor cortex.
对4头患有韦弗综合征的成年瑞士褐牛和2头健康牛（1头荷斯坦公牛和1头根西奶牛）大脑的运动皮质突触进行了超微结构比较。与健康牛相比，患有韦弗综合征的牛突触连接处的膜旁密度显示，突触前致密突起的平均高度降低（P<0.001），峰峰间距显著变小（P<0.001），突触后致密的平均厚度显著降低（P<0.0001）。患有韦弗综合征的牛的这些突触变化可能与该综合征的临床表现有关，如神经递质释放受损、突触后受体位点不稳定、中枢神经系统其他部位损伤引起的损伤诱导突触更新，或运动皮质特定细胞群的丧失。
