Ren Wenjing, Wei Yuran, Lian Guanping, Yang Chuwei, Liu Yufei
Emergency Department, The Second Hospital of Dalian Medical University, No. 467 Zhongshan Road, Dalian City, Liaoning Province, P.R. China.
BMC Infect Dis. 2025 May 15;25(1):704. doi: 10.1186/s12879-025-11094-z.
Lactobacillus plantarum is a probiotic. It has a positive effect on the intestinal flora, improving intestinal barrier function and regulating immune function. At present, it is clinically used to prevent or treat a variety of diseases. However, in recent years, serious infections caused by Lactobacillus plantarum have been reported. Endoscopic retrograde cholangiopancreatography (ERCP) is one of the main methods for managing biliary and pancreatic disorders. With the widespread application of ERCP, there are increasing reports of concurrent infections.
In this case, a 62-year-old female patient with pancreatic cancer developed chills and fever after undergoing ERCP and biliary stenting. She was diagnosed with a liver abscess, and the pathogenic bacterium identified was Lactobacillus plantarum, a rare instance of a probiotic causing disease.
This report describes the first case of a liver abscess caused by Lactobacillus plantarum following ERCP. This suggests that although Lactobacillus plantarum is a probiotic, it is risky for patients with anatomical disruptions, impaired mucosal barrier function, or immunocompromised status. Clinical applications of Lactobacillus plantarum should be treated with caution.
植物乳杆菌是一种益生菌。它对肠道菌群有积极作用，可改善肠道屏障功能并调节免疫功能。目前，它在临床上用于预防或治疗多种疾病。然而，近年来，已有植物乳杆菌引起严重感染的报道。内镜逆行胰胆管造影术（ERCP）是处理胆胰疾病的主要方法之一。随着ERCP的广泛应用，并发感染的报道越来越多。
在本病例中，一名62岁的胰腺癌女性患者在接受ERCP和胆道支架置入术后出现寒战和发热。她被诊断为肝脓肿，鉴定出的病原菌是植物乳杆菌，这是益生菌致病的罕见病例。
本报告描述了首例ERCP术后由植物乳杆菌引起的肝脓肿病例。这表明尽管植物乳杆菌是一种益生菌，但对于存在解剖结构破坏、黏膜屏障功能受损或免疫功能低下的患者来说，仍存在风险。植物乳杆菌的临床应用应谨慎对待。
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