Li Peizhi, An Guohua
Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, USA.
Clin Pharmacol Ther. 2025 Sep;118(3):548-550. doi: 10.1002/cpt.3717. Epub 2025 May 15.
The rising cases of cannabis-impaired driving present a looming public safety concern that's currently addressed through varying state regulations. However, these regulations are yet validated and lack scientific robustness. One of the roadblocking factors is our insufficient understanding of THC's pharmacokinetics (PK) and pharmacodynamics (PD) due to limited clinical data. Therefore, we call for joint efforts among researchers and policymakers to conduct more comprehensive cannabis PK/PD studies to improve and validate existing cannabis driving regulations.
大麻影响下驾驶的案例不断增加，这引发了一个迫在眉睫的公共安全问题，目前各州通过不同的法规来应对这一问题。然而，这些法规尚未得到验证，缺乏科学稳健性。阻碍因素之一是由于临床数据有限，我们对四氢大麻酚的药代动力学（PK）和药效学（PD）了解不足。因此，我们呼吁研究人员和政策制定者共同努力，开展更全面的大麻PK/PD研究，以改进和验证现有的大麻驾驶法规。
