Gregory J A, Schiller W R
Am Surg. 1985 Sep;51(9):534-6.
The subclavian catheter is commonly used in burn and trauma patients but remains a significant source of bacterial invasion in this group of seriously compromised individuals. The authors arbitrarily decided to change the catheter routinely every 3 days in consecutive patients to evaluate whether early detection of colonization and lowering of the infection rate was possible with this technique. At the time of change, catheter tips and central venous blood samples were sent for culture. Twenty-four venous blood samples were sent for culture. Twenty-four patients were studied in whom a total of 143 catheter changes over a wire introducer were performed. There were 20 men and four women with an average age of 34.5 years. Twenty patients with burns (average 48% body surface area involved), two patients with abdominal gunshot wounds, and two patients with complicated blunt trauma were studied. Five patients (three burns, two trauma) died, four because of sepsis, one of respiratory failure. Forty of the 143 catheter tips yielded positive cultures; however, 26 of these were not associated with overt sepsis. This 28 per cent incidence of positive catheter cultures was significantly less than the 47 per cent incidence reported previously in an identical patient population in whom the catheter was changed and cultured on clinical suspicion of sepsis (P value less than 0.001). There were 38 clinical episodes of sepsis, but the catheter could be implicated as the source in only five of these. Pseudomonas was the most common organism isolated from all sources. The authors conclude from this study that the incidence of positive catheters is significant in this high-risk group, but is decreased when the routine change protocol is implemented.(ABSTRACT TRUNCATED AT 250 WORDS)
锁骨下静脉导管常用于烧伤和创伤患者,但在这群严重受损的个体中,它仍是细菌入侵的重要来源。作者随意决定对连续的患者每3天常规更换导管,以评估通过该技术是否有可能早期检测到定植并降低感染率。更换导管时,将导管尖端和中心静脉血样本送去培养。共送检了24份静脉血样本进行培养。对24例患者进行了研究,共通过导丝进行了143次导管更换。其中男性20例,女性4例,平均年龄34.5岁。研究对象包括20例烧伤患者(平均烧伤面积为体表面积的48%)、2例腹部枪伤患者和2例复杂钝性创伤患者。5例患者(3例烧伤,2例创伤)死亡,4例死于败血症,1例死于呼吸衰竭。143个导管尖端中有40个培养结果呈阳性;然而,其中26个与明显的败血症无关。导管培养阳性率为28%,显著低于先前在相同患者群体中报告的47%,先前该群体是在临床怀疑败血症时更换导管并进行培养(P值小于0.001)。有38例临床败血症发作,但其中只有5例可将导管认定为感染源。假单胞菌是从所有来源分离出的最常见病原体。作者从这项研究得出结论,在这个高危群体中,导管培养阳性率很高,但实施常规更换方案后该率会降低。(摘要截短至250字)