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保守治疗广泛性牙源性黏液瘤患者的康复:一项随访14年的病例报告

Rehabilitation of a patient with extensive odontogenic myxoma treated conservatively: A case report with 14 years of follow-up.

作者信息

Paz Ana L L M, Leite Cristhiane A, Mariz Bruno A L A, Volpato Luiz E R, Rocha André C

机构信息

School of Dentistry, University of Cuiabá, Cuiabá, MT, Brazil.

Department of Dentistry, Mato Grosso Cancer Hospital, Cuiabá, MT, Brazil.

出版信息

J Clin Exp Dent. 2025 Apr 1;17(4):e488-e492. doi: 10.4317/jced.62679. eCollection 2025 Apr.

DOI:10.4317/jced.62679
PMID:40375841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12077831/
Abstract

Odontogenic myxoma is an odontogenic tumor of mesenchymal origin that presents locally invasive behavior. Its treatment is surgical, and the approach can be more conservative or radical. This article presents the rehabilitation of a patient with extensive odontogenic myxoma in the mandible treated conservatively with follow-up for 14 years. A 17-year-old male patient sought care with a painless swelling in the mandibular region causing facial asymmetry. Imaging exams showed a mixed image, with intralesional septa, involving the left anterior and posterior regions of the mandible with a small remaining basilar and lingual bone. An incisional biopsy was performed which confirmed the diagnosis of odontogenic myxoma. Due to the extent of the lesion, a conservative approach was chosen, with excision of the lesion and peripheral ostectomy, with recurrence of the lesion after 48 months, with a new approach being performed. After 14 years of follow-up, without further recurrence of the lesion, the patient was rehabilitated with dental implants and protocol-type prosthesis. Conservative treatment led to bone remodeling and enabled patient rehabilitation with oral implants and an implant-supported prosthesis. Thus, conservative treatment of odontogenic myxomas is a viable alternative for similar cases, and its longitudinal postoperative follow-up is essential. Conservative Treatment, Dental Implants, Myxoma; Oral Pathology, Oral Surgery.

摘要

牙源性黏液瘤是一种间充质起源的牙源性肿瘤,具有局部侵袭性。其治疗方法为手术,手术方式可较为保守或激进。本文介绍了一名下颌骨广泛牙源性黏液瘤患者的治疗情况,该患者接受了保守治疗并随访14年。一名17岁男性患者因下颌区域无痛性肿胀导致面部不对称前来就诊。影像学检查显示为混合影像,瘤内有间隔,累及下颌骨左前和后区域,仅残留少量基底骨和舌侧骨。进行了切开活检,确诊为牙源性黏液瘤。由于病变范围,选择了保守治疗方法,即切除病变及周边骨切除术,48个月后病变复发,遂采取新的治疗方法。经过14年的随访,病变未再次复发,患者通过牙种植体和定制型假体进行了修复。保守治疗导致骨重塑,并使患者能够通过口腔种植体和种植体支持的假体进行修复。因此,牙源性黏液瘤的保守治疗是类似病例的一种可行选择,术后长期随访至关重要。保守治疗、牙种植体、黏液瘤;口腔病理学、口腔外科。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed19/12077831/a3b59ecba0c8/jced-17-e488-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed19/12077831/67ca7d8b84e2/jced-17-e488-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed19/12077831/36bf18e15383/jced-17-e488-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed19/12077831/bce2f707c50a/jced-17-e488-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed19/12077831/a3b59ecba0c8/jced-17-e488-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed19/12077831/67ca7d8b84e2/jced-17-e488-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed19/12077831/36bf18e15383/jced-17-e488-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed19/12077831/bce2f707c50a/jced-17-e488-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed19/12077831/a3b59ecba0c8/jced-17-e488-g004.jpg

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本文引用的文献

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Mandibular Reconstruction With Fibula Flap and Dental Implants Through Virtual Surgical Planning and Three Different Techniques: Double-Barrel Flap, Implant Dynamic Navigation and CAD/CAM Mesh With Iliac Crest Graft.通过虚拟手术规划和三种不同技术进行腓骨瓣和牙种植体下颌骨重建:双筒瓣、种植体动态导航以及带髂嵴移植的CAD/CAM网片。
Front Oncol. 2021 Oct 5;11:719712. doi: 10.3389/fonc.2021.719712. eCollection 2021.
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Odontogenic Myxoma: Follow-Up of 13 cases after conservative surgical treatment and review of the literature.牙源性黏液瘤:13例保守性手术治疗后的随访及文献复习
J Clin Exp Dent. 2021 Jul 1;13(7):e637-e641. doi: 10.4317/jced.58080. eCollection 2021 Jul.
3
Central Odontogenic Myxoma: A Radiographic Analysis.
中央型牙源性黏液瘤:影像学分析
Int J Dent. 2021 Jun 28;2021:1093412. doi: 10.1155/2021/1093412. eCollection 2021.
4
Odontogenic Myxoma: A 23-Year Retrospective Series of 38 Cases.牙源性黏液瘤:38 例 23 年回顾性系列研究。
Head Neck Pathol. 2020 Dec;14(4):1021-1027. doi: 10.1007/s12105-020-01191-7. Epub 2020 Jun 6.
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Odontogenic Myxoma: Systematic review and bias analysis.牙源性黏液瘤:系统评价和偏倚分析。
Eur J Clin Invest. 2020 Apr;50(4):e13214. doi: 10.1111/eci.13214. Epub 2020 Mar 14.
6
Odontogenic myxomas: what is the ideal treatment?牙源性黏液瘤:理想的治疗方法是什么?
BMJ Case Rep. 2019 May 21;12(5):e228540. doi: 10.1136/bcr-2018-228540.
7
Long-Term Follow-Up after Conservative Surgical Treatment of Odontogenic Myxoma: A Case Report and Literature Review.牙源性黏液瘤保守性手术治疗后的长期随访:一例报告及文献综述
Case Rep Dent. 2019 Feb 11;2019:1634842. doi: 10.1155/2019/1634842. eCollection 2019.
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Appropriate surgical margin for odontogenic myxoma: a review of 12 cases.牙源性黏液瘤的适当手术切缘:12 例回顾。
Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Nov;126(5):404-408. doi: 10.1016/j.oooo.2018.06.002. Epub 2018 Jun 25.
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Odontogenic myxoma: An updated analysis of 1,692 cases reported in the literature.牙源性黏液瘤:文献中 1692 例病例的更新分析。
Oral Dis. 2019 Apr;25(3):676-683. doi: 10.1111/odi.12875. Epub 2018 Jun 8.
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