Sicher Avery R, Liss Andrea, Vozella Valentina, Marsland Paige, Seemiller Laurel R, Springer Matthew, Starnes William D, Griffith Keith R, Smith Grace C, Astefanous Amy, Deak Terrence, Roberto Marisa, Varodayan Florence P, Crowley Nicole A
Neuroscience Graduate Program, The Huck Institute of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Addict Neurosci. 2024 Sep;12. doi: 10.1016/j.addicn.2024.100171. Epub 2024 Aug 3.
Adolescence is a period of increased risk taking, including increased alcohol and drug use. Multiple clinical studies report a positive relationship between adolescent alcohol consumption and risk of developing an alcohol use disorder (AUD) in adulthood. However, few preclinical studies have attempted to tease apart the biological contributions of adolescent alcohol exposure, independent of other social, environmental, and stress factors, and studies that have been conducted show mixed results. Here we use several adolescent voluntary consumption of alcohol models, conducted across four labs in three institutes and with two rodent species, to investigate the ramifications of adolescent alcohol consumption on adulthood alcohol consumption in controlled, pre-clinical environments. We consistently demonstrate a lack of robust increases in adulthood alcohol consumption. This work highlights that risks seen in both human datasets and other murine drinking models may be due to unique social and environmental factors - some of which may be unique to humans.
青春期是一个冒险行为增加的时期，包括酒精和药物使用的增加。多项临床研究报告称，青少年饮酒与成年后患酒精使用障碍（AUD）的风险之间存在正相关关系。然而，很少有临床前研究试图区分青少年酒精暴露的生物学影响，而不考虑其他社会、环境和压力因素，并且已进行的研究结果不一。在这里，我们使用了几种青少年自愿饮酒模型，这些模型在三个机构的四个实验室中对两种啮齿动物物种进行了实验，以研究在可控的临床前环境中青少年饮酒对成年期饮酒的影响。我们一致证明成年期饮酒量没有显著增加。这项工作强调，在人类数据集和其他小鼠饮酒模型中看到的风险可能是由于独特的社会和环境因素——其中一些因素可能是人类所特有的。
