Xiang Weiyi, Jiang Xian, Guo Linghong
Department of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Dis-Ease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Drug Des Devel Ther. 2025 May 10;19:3805-3825. doi: 10.2147/DDDT.S519048. eCollection 2025.
Microneedles can physically penetrate the stratum corneum, creating micropores on the skin, and allowing for drug delivery through direct diffusion, injection, or other methods. As a novel drug delivery method, it possesses significant application potential. This study uses bibliometric analysis to explore the research hotspots and development trends of microneedle-mediated drug delivery.
Relevant research articles on microneedle-mediated drug delivery published between 1998 and 2024 in the Web of Science Core Collection (WoSCC) database were retrieved. Data analysis and visualization were performed using VOSviewer, CiteSpace, Scimago Graphica, and Pajek, enabling the prediction of research trends in microneedle-mediated drug delivery.
In general, research on microneedle-mediated drug delivery has shown a continuous increase. China and the United States are the leading countries in this field of study. Notably, Ryan F. Donnelly (n=224) is the most prominent contributor to this field. The current core research directions include: disease treatment, enhancement of transdermal absorption performance of microneedles, vaccine delivery, and new materials and technologies for microneedle manufacturing.
Microneedle-mediated drug delivery, as a novel technology and method, holds significant research value and application potential. However, further strengthening of international collaboration and the clinical translation of research findings are needed.
微针能够物理穿透角质层，在皮肤上形成微孔，并允许通过直接扩散、注射或其他方法进行药物递送。作为一种新型的药物递送方法，它具有巨大的应用潜力。本研究采用文献计量分析方法，探讨微针介导药物递送的研究热点和发展趋势。
检索了1998年至2024年期间发表在科学引文索引核心合集（WoSCC）数据库中有关微针介导药物递送的相关研究文章。使用VOSviewer、CiteSpace、Scimago Graphica和Pajek进行数据分析和可视化，从而预测微针介导药物递送的研究趋势。
总体而言，微针介导药物递送的研究呈持续增长态势。中国和美国是该研究领域的领先国家。值得注意的是，瑞安·F·唐纳利（Ryan F. Donnelly，发文量n = 224）是该领域最杰出的贡献者。当前的核心研究方向包括：疾病治疗、提高微针的透皮吸收性能、疫苗递送以及微针制造的新材料和新技术。
微针介导药物递送作为一种新技术和方法，具有重要的研究价值和应用潜力。然而，需要进一步加强国际合作以及研究成果的临床转化。
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