Kong Li, Tian Xiaohong, Ji Bing, Wang Jian, Liang Hongqin, Ji Xiaojuan
Department of Ultrasound, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Engineering Research Center of Stem Cell Therapy, Chongqing, China.
Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Front Cardiovasc Med. 2025 May 1;12:1553919. doi: 10.3389/fcvm.2025.1553919. eCollection 2025.
To investigate the feasibility of using native longitudinal relaxation time (T1) mapping values, derived from the Picture Archiving and Communication System (PACS), for assessing diffuse myocardial fibrosis in patients with coronary heart disease (CHD).
Patients with CHD group were retrospectively enrolled as the experimental group, while age- and sex-matched healthy individuals were included as the control group. Based on the results of late gadolinium enhancement (LGE) sequence from cardiac magnetic resonance (CMR) imaging, the CHD group was further stratified into two subgroups: the LGE positive group (LGE+) and the LGE negative group (LGE-). The correlation between native T1 values and extracellular volume (ECV) values were assessed using the Pearson correlation coefficient.
A total of 60 patients with coronary heart disease (age 54.03 ± 9.86 years) were included in the analysis, of whom 30 had late gadolinium enhancement (LGE+) and 30 did not (LGE-). The control group consisted of 42 healthy subjects (age 52.14 ± 7.41 years). Compared with the control group, both native T1 and extracellular volume (ECV) values were significantly increased in the CHD group ( < 0.05). The native T1 value was positively correlated with the ECV value ( = 0.711, < 0.01). In the LGE+ subgroup, native T1 and ECV values were significantly higher than those in the control group ( < 0.001). The area under the receiver operating characteristic curve (AUC) for native T1 was 0.763. The optimal diagnostic threshold for native T1, as measured by the Picture Archiving and Communication System (PACS), was 1,275.50 ms, with a sensitivity of 93.3% and a specificity of 63.3%.
The diagnostic performance of scanner-generated native T1 Mapping demonstrates robust accuracy and holds potential as a non-invasive tool for evaluating diffuse myocardial fibrosis in patients with CHD.
探讨利用源自图像存档与通信系统（PACS）的固有纵向弛豫时间（T1）映射值评估冠心病（CHD）患者弥漫性心肌纤维化的可行性。
回顾性纳入冠心病患者作为实验组，纳入年龄和性别匹配的健康个体作为对照组。根据心脏磁共振（CMR）成像的延迟钆增强（LGE）序列结果，冠心病组进一步分为两个亚组：LGE阳性组（LGE+）和LGE阴性组（LGE-）。采用Pearson相关系数评估固有T1值与细胞外容积（ECV）值之间的相关性。
共纳入60例冠心病患者（年龄54.03±9.86岁）进行分析，其中30例有延迟钆增强（LGE+），30例无（LGE-）。对照组由42名健康受试者组成（年龄52.14±7.41岁）。与对照组相比，冠心病组的固有T1值和细胞外容积（ECV）值均显著升高（<0.05）。固有T1值与ECV值呈正相关（=0.711，<0.01）。在LGE+亚组中，固有T1值和ECV值显著高于对照组（<0.001）。固有T1的受试者工作特征曲线（AUC）下面积为0.763。通过图像存档与通信系统（PACS）测量的固有T1的最佳诊断阈值为1275.50 ms，敏感性为93.3%，特异性为63.3%。
扫描仪生成的固有T1映射的诊断性能显示出强大的准确性，作为评估冠心病患者弥漫性心肌纤维化的非侵入性工具具有潜力。
