Huang Qianhao, Xiong Dongfeng, Huang Yifan, Zhuang Xuan, Chen Yuedong
The Key Laboratory of Urinary Tract Tumours and Calculi, Department of Urology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
The School of Clinical Medicine, Fujian Medical University, Fuzhou, China.
Transl Androl Urol. 2025 Apr 30;14(4):1138-1146. doi: 10.21037/tau-24-616. Epub 2025 Apr 27.
Penile cancer is a relatively uncommon malignancy. It is most commonly a squamous cell carcinoma (SCC), but other non-squamous malignancies, including basal cell carcinoma, melanoma, sarcoma, metastatic carcinoma and adenosquamous cell carcinoma, have also been documented. Primary adenosquamous carcinoma of the penis (ASC) is an uncommon variant of SCC, accounting for approximately 1-2% of all SCC cases.
A 77-year-old male presented to The First Affiliated Hospital of Xiamen University with an enlarged penile head, persistent pain, urinary tract infection, and dilute urine, which had progressively worsened over the past month. Specialist examination showed normal penile development without malformation, but the foreskin was long and could not be turned up and was circumcised. The patient underwent surgical intervention, followed by regular reviews and subsequent follow-ups. A review of the literature reveals that only 13 cases have been documented since 1986, and there is a paucity of relevant literature available for review and update.
This paper aims to present a case of ASC in an elderly male with a chief complaint of 'pain' and to provide a comprehensive overview of the aetiology, epidemiology, clinical presentation, histopathology, diagnosis and treatment options of ASC. In short, the treatment plan and outcome of this case offer a valuable reference point for the selection and optimisation of treatment modalities for this disease.
阴茎癌是一种相对罕见的恶性肿瘤。它最常见的是鳞状细胞癌（SCC），但其他非鳞状恶性肿瘤，包括基底细胞癌、黑色素瘤、肉瘤、转移性癌和腺鳞癌，也有文献记载。原发性阴茎腺鳞癌（ASC）是SCC的一种罕见变体，约占所有SCC病例的1-2%。
一名77岁男性因阴茎头肿大、持续性疼痛、尿路感染和尿液稀释，到厦门大学附属第一医院就诊，这些症状在过去一个月里逐渐加重。专科检查显示阴茎发育正常，无畸形，但包皮过长，无法上翻，已行包皮环切术。患者接受了手术干预，随后进行定期复查和随访。文献回顾显示，自1986年以来仅有13例病例记录，且可供查阅和更新的相关文献匮乏。
本文旨在介绍一例以“疼痛”为主诉的老年男性ASC病例，并全面概述ASC的病因、流行病学、临床表现、组织病理学、诊断和治疗选择。简而言之，该病例的治疗方案和结果为这种疾病治疗方式的选择和优化提供了有价值的参考点。
