Juliano Vitor Augusto Laurino, Albernaz-Mariano Kairo Alan, Covre Luiza Helena Halas, Jucá Paloma Marinho, Pereira Robbert Mota, Shigeo-de-Almeida Amadeu, Sampaio Lucas Luzia, Duque Erica de Almeida, Munhoz Carolina Demarchi
Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.
Front Neurosci. 2025 May 1;19:1548372. doi: 10.3389/fnins.2025.1548372. eCollection 2025.
Substance use has been intertwined with human history for millennia. Throughout the ages, people have consumed various substances for medicinal, spiritual, and recreational reasons, although occasional use differs significantly from substance use disorders (SUDs). Exposure to lifetime stressors constitutes a significant risk factor for both psychiatric disorders and SUD development and relapse. Indeed, hypothalamic-pituitary-adrenal (HPA) axis modulation, alterations in neuroanatomical and neurotransmitter systems, as well as neuroinflammation are common features of stress-related mood disorders and SUDs. In this mini-review, we will explore how stress exposure influences the SUDs' neurobiological basis on different scales-from large neural circuitries to specific molecular mechanisms-and discuss novel targets for potential treatments.
数千年来，物质使用一直与人类历史交织在一起。从古至今，人们出于医疗、精神和娱乐等原因使用各种物质，尽管偶尔使用与物质使用障碍（SUDs）有很大不同。一生中暴露于应激源是精神疾病以及SUDs发生和复发的重要风险因素。事实上，下丘脑-垂体-肾上腺（HPA）轴调节、神经解剖和神经递质系统的改变以及神经炎症是与应激相关的情绪障碍和SUDs的共同特征。在这篇小型综述中，我们将探讨应激暴露如何在不同尺度上影响SUDs的神经生物学基础——从大的神经回路到特定的分子机制——并讨论潜在治疗的新靶点。
