舌下使用阿托品滴眼液治疗氯氮平引起的流涎症。
Sublingual use of atropine eye drops for the treatment of clozapine induced sialorrhea.
作者信息
Saha Anirban, Singh Ayush, Nandan Neethu K, Das Shrayasi, Somani Aditya
机构信息
Department of Psychiatry, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.
出版信息
Ind Psychiatry J. 2025 Jan-Apr;34(1):123-125. doi: 10.4103/ipj.ipj_352_24. Epub 2025 Jan 15.
Abstract
Clozapine is the drug of choice for patients with treatment-resistant schizophrenia. However, it has a variety of adverse effects. Sialorrhea is a bothersome side effect that can have an impact on both medical and psychosocial aspects. There is limited literature on the use of 1% atropine eye drops sublingually for the treatment of clozapine-induced sialorrhea (CIS). In this case series, we report three patients of CIS treated successfully with 1% atropine eye drops given sublingually.
摘要
氯氮平是治疗难治性精神分裂症患者的首选药物。然而，它有多种不良反应。流涎是一种令人烦恼的副作用，会对医学和心理社会方面都产生影响。关于舌下使用1%阿托品滴眼液治疗氯氮平引起的流涎（CIS）的文献有限。在这个病例系列中，我们报告了3例舌下给予1%阿托品滴眼液成功治疗的CIS患者。
相似文献
1
Sublingual use of atropine eye drops for the treatment of clozapine induced sialorrhea.
Ind Psychiatry J. 2025 Jan-Apr;34(1):123-125. doi: 10.4103/ipj.ipj_352_24. Epub 2025 Jan 15.
2
[Sublingual use of atropine for clozapine-induced sialorrhoea: literature review and two case reports].
Tijdschr Psychiatr. 2019;61(6):403-410.
3
The effect of sublingual atropine sulfate on clozapine-induced hypersalivation: a multicentre, randomised placebo-controlled trial.
Psychopharmacology (Berl). 2020 Oct;237(10):2905-2915. doi: 10.1007/s00213-020-05627-4. Epub 2020 Sep 2.
4
Evaluation and Comparison of the Effectiveness of Atropine Eye Drops, Ipratropium Bromide Nasal Spray, and Amitriptyline Tablet in the Management of Clozapine-Associated Sialorrhea in Patients With Refractory Schizophrenia: A Randomized Clinical Trial.
J Clin Psychopharmacol. 2024;44(1):9-15. doi: 10.1097/JCP.0000000000001786.
5
Sublingual Atropine Administration for Clozapine-Induced Sialorrhea in Bipolar Disorder: A Case Report Highlighting its Efficacy, Safety Concerns and Challenges.
Psychopharmacol Bull. 2024 Aug 19;54(4):124-130.
6
Sublingual administration of atropine eye drops for treating sialorrhea after stroke: A randomized controlled trial.
J Stroke Cerebrovasc Dis. 2024 Dec;33(12):108050. doi: 10.1016/j.jstrokecerebrovasdis.2024.108050. Epub 2024 Oct 2.
7
The sublingual use of atropine in the treatment of clozapine-induced sialorrhea: A systematic review.
Clin Case Rep. 2019 Sep 27;7(11):2108-2113. doi: 10.1002/ccr3.2431. eCollection 2019 Nov.
8
Use of atropine eye drops for clozapine induced hypersalivation.
Aust N Z J Psychiatry. 2000 Dec;34(6):1033-4. doi: 10.1177/000486740003400102.
9
Sublingual atropine drops for the treatment of pediatric sialorrhea.
J Pain Symptom Manage. 2010 Nov;40(5):783-8. doi: 10.1016/j.jpainsymman.2010.02.007. Epub 2010 Jun 11.
10
Prevalence of clozapine-induced sialorrhea and its effect on quality of life.
Psychopharmacology (Berl). 2023 Jan;240(1):203-211. doi: 10.1007/s00213-022-06294-3. Epub 2022 Dec 20.
本文引用的文献
1
The effect of sublingual atropine sulfate on clozapine-induced hypersalivation: a multicentre, randomised placebo-controlled trial.
Psychopharmacology (Berl). 2020 Oct;237(10):2905-2915. doi: 10.1007/s00213-020-05627-4. Epub 2020 Sep 2.
2
Sublingual atropine in the treatment of clozapine-induced sialorrhea.
Schizophr Res. 2017 Apr;182:144-145. doi: 10.1016/j.schres.2016.10.039. Epub 2016 Nov 2.
3
Clozapine-induced hypersalivation: an estimate of prevalence, severity and impact on quality of life.
Ther Adv Psychopharmacol. 2016 Jun;6(3):178-84. doi: 10.1177/2045125316641019. Epub 2016 Mar 30.
4
Sublingual atropine for the treatment of severe and hyoscine-resistant clozapine-induced sialorrhea.
Afr J Psychiatry (Johannesbg). 2013 Jul;16(4):242. doi: 10.4314/ajpsy.v16i4.32.
5
Aspiration Pneumonia Due to Clozapine-Induced Sialorrhea.
Clin Schizophr Relat Psychoses. 2016 Winter;9(4):170-2. doi: 10.3371/CSRP.SAFI.061213. Epub 2013 Jun 17.
6
Parasympathetic vasoactive intestinal peptide (VIP): a likely contributor to clozapine-induced sialorrhoea.
Oral Dis. 2014 Apr;20(3):e90-6. doi: 10.1111/odi.12139. Epub 2013 Jun 4.
7
Pharmacological interventions for clozapine-induced hypersalivation.
Cochrane Database Syst Rev. 2008 Jul 16;2008(3):CD005579. doi: 10.1002/14651858.CD005579.pub2.
8
Clozapine-induced sialorrhea: pathophysiology and management strategies.
Psychopharmacology (Berl). 2006 Apr;185(3):265-73. doi: 10.1007/s00213-005-0248-4. Epub 2006 Mar 3.
9
Intraoral application of atropine sulfate ophthalmic solution for clozapine-induced sialorrhea.
Ann Pharmacother. 2004 Sep;38(9):1538. doi: 10.1345/aph.1E077. Epub 2004 Jul 13.
10
Use of atropine eye drops for clozapine induced hypersalivation.
Aust N Z J Psychiatry. 2000 Dec;34(6):1033-4. doi: 10.1177/000486740003400102.
Zotero 插件