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本文引用的文献

1
The effect of sublingual atropine sulfate on clozapine-induced hypersalivation: a multicentre, randomised placebo-controlled trial.硫酸舌下阿托品对氯氮平引起的唾液分泌过多的影响：一项多中心、随机、安慰剂对照试验。
Psychopharmacology (Berl). 2020 Oct;237(10):2905-2915. doi: 10.1007/s00213-020-05627-4. Epub 2020 Sep 2.
2
Sublingual atropine in the treatment of clozapine-induced sialorrhea.舌下含服阿托品治疗氯氮平引起的流涎症。
Schizophr Res. 2017 Apr;182:144-145. doi: 10.1016/j.schres.2016.10.039. Epub 2016 Nov 2.
3
Clozapine-induced hypersalivation: an estimate of prevalence, severity and impact on quality of life.氯氮平引起的唾液分泌过多：患病率、严重程度及对生活质量影响的评估
Ther Adv Psychopharmacol. 2016 Jun;6(3):178-84. doi: 10.1177/2045125316641019. Epub 2016 Mar 30.
4
Sublingual atropine for the treatment of severe and hyoscine-resistant clozapine-induced sialorrhea.舌下含服阿托品治疗严重且对东莨菪碱耐药的氯氮平所致流涎症。
Afr J Psychiatry (Johannesbg). 2013 Jul;16(4):242. doi: 10.4314/ajpsy.v16i4.32.
5
Aspiration Pneumonia Due to Clozapine-Induced Sialorrhea.氯氮平所致流涎引起的吸入性肺炎
Clin Schizophr Relat Psychoses. 2016 Winter;9(4):170-2. doi: 10.3371/CSRP.SAFI.061213. Epub 2013 Jun 17.
6
Parasympathetic vasoactive intestinal peptide (VIP): a likely contributor to clozapine-induced sialorrhoea.副交感神经血管活性肠肽（VIP）：氯氮平所致流涎的可能促成因素。
Oral Dis. 2014 Apr;20(3):e90-6. doi: 10.1111/odi.12139. Epub 2013 Jun 4.
7
Pharmacological interventions for clozapine-induced hypersalivation.氯氮平所致流涎的药物干预措施。
Cochrane Database Syst Rev. 2008 Jul 16;2008(3):CD005579. doi: 10.1002/14651858.CD005579.pub2.
8
Clozapine-induced sialorrhea: pathophysiology and management strategies.氯氮平所致流涎：病理生理学及管理策略
Psychopharmacology (Berl). 2006 Apr;185(3):265-73. doi: 10.1007/s00213-005-0248-4. Epub 2006 Mar 3.
9
Intraoral application of atropine sulfate ophthalmic solution for clozapine-induced sialorrhea.硫酸阿托品滴眼液经口腔内应用治疗氯氮平所致流涎症。
Ann Pharmacother. 2004 Sep;38(9):1538. doi: 10.1345/aph.1E077. Epub 2004 Jul 13.
10
Use of atropine eye drops for clozapine induced hypersalivation.使用阿托品滴眼液治疗氯氮平引起的流涎过多。
Aust N Z J Psychiatry. 2000 Dec;34(6):1033-4. doi: 10.1177/000486740003400102.

舌下使用阿托品滴眼液治疗氯氮平引起的流涎症。

Sublingual use of atropine eye drops for the treatment of clozapine induced sialorrhea.

作者信息

Saha Anirban, Singh Ayush, Nandan Neethu K, Das Shrayasi, Somani Aditya

机构信息

Department of Psychiatry, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.

出版信息

Ind Psychiatry J. 2025 Jan-Apr;34(1):123-125. doi: 10.4103/ipj.ipj_352_24. Epub 2025 Jan 15.

DOI:10.4103/ipj.ipj_352_24
PMID:40376653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12077623/
Abstract

Clozapine is the drug of choice for patients with treatment-resistant schizophrenia. However, it has a variety of adverse effects. Sialorrhea is a bothersome side effect that can have an impact on both medical and psychosocial aspects. There is limited literature on the use of 1% atropine eye drops sublingually for the treatment of clozapine-induced sialorrhea (CIS). In this case series, we report three patients of CIS treated successfully with 1% atropine eye drops given sublingually.

摘要

氯氮平是治疗难治性精神分裂症患者的首选药物。然而，它有多种不良反应。流涎是一种令人烦恼的副作用，会对医学和心理社会方面都产生影响。关于舌下使用1%阿托品滴眼液治疗氯氮平引起的流涎（CIS）的文献有限。在这个病例系列中，我们报告了3例舌下给予1%阿托品滴眼液成功治疗的CIS患者。