Maher Senan, Cunningham Aoife, O'Callaghan Niamh, Byrne Fintan, Mc Donald Colm, McInerney Shane, Hallahan Brian
National University of Ireland Galway, Clinical Sciences Institute, Galway, Ireland.
National University of Ireland Galway, Ireland.
Ther Adv Psychopharmacol. 2016 Jun;6(3):178-84. doi: 10.1177/2045125316641019. Epub 2016 Mar 30.
The objective of this study was to evaluate the prevalence and severity of clozapine-induced hypersalivation, and assess the impact hypersalivation has on global functioning.
Participants attending a dedicated clozapine clinic were invited to undertake a structured interview regarding their experiences of clozapine-induced hypersalivation. Two psychometric instruments to measure hypersalivation, the Nocturnal Hypersalivation Rating Scale and the Drooling Severity and Frequency Scale were used.
Clozapine-induced hypersalivation was experienced by 92% of participants, with nocturnal hypersalivation more prevalent compared to daytime hypersalivation (85% versus 48%). Daytime drooling was severe in 18% of cases and was present on a frequent or constant basis for 20% of individuals. Hypersalivation had at least a moderate impact on the quality of life of 15% of study participants.
Clozapine-induced hypersalivation is the most prevalent adverse effect experienced by patients treated with clozapine and negatively impacts on quality of life, particularly if daytime drooling is present. The development of further strategies to ameliorate this adverse effect is required given the demonstrated lack of success to date in managing this condition.
本研究的目的是评估氯氮平所致流涎的发生率和严重程度，并评估流涎对整体功能的影响。
邀请到专门的氯氮平诊所就诊的参与者就其氯氮平所致流涎的经历进行结构化访谈。使用了两种测量流涎的心理测量工具，即夜间流涎评定量表和流涎严重程度及频率量表。
92%的参与者经历过氯氮平所致流涎，夜间流涎比白天流涎更普遍（85%对48%）。18%的病例白天流口水严重，20%的个体频繁或持续出现白天流口水的情况。流涎对15%的研究参与者的生活质量至少有中度影响。
氯氮平所致流涎是接受氯氮平治疗的患者最普遍的不良反应，对生活质量有负面影响，尤其是在存在白天流口水的情况下。鉴于目前在管理这种情况方面缺乏成功案例，需要制定进一步的策略来改善这种不良反应。
