Hu Chunhua, Chen Lingyi, Ding Yi, Ye Mujie, Tang Qiyun
Shanghai Key Laboratory of Gut Microecology and Associated Major Diseases Research, Digestive Disease Research and Clinical Translation Center, Department of Gastroenterology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Neuroendocrine Tumor Diagnosis and Treatment Center, Jiangsu Province Hospital, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Cell Mol Life Sci. 2025 May 16;82(1):205. doi: 10.1007/s00018-025-05656-2.
Neuroendocrine neoplasms (NENs) are a group of highly heterogeneous neoplasms originating from neuroendocrine cells with a gradually increased incidence. Metabolic change is one of the recognized markers of tumor progression, which has been extensively and systematically studied in other malignant tumors. However, metabolic change in NENs has been relatively poorly studied, and systematic reviews are lacking. We reviewed the relationship between metabolic changes and NENs from the aspects of glucose metabolism, lipid metabolism, metabolic syndrome, amino acid metabolism and metabolomics, and discussed the potential therapeutic strategies of metabolic changes for NENs.
神经内分泌肿瘤（NENs）是一组起源于神经内分泌细胞的高度异质性肿瘤，其发病率呈逐渐上升趋势。代谢改变是肿瘤进展的公认标志物之一，在其他恶性肿瘤中已得到广泛而系统的研究。然而，NENs中的代谢改变研究相对较少，且缺乏系统评价。我们从糖代谢、脂代谢、代谢综合征、氨基酸代谢和代谢组学等方面综述了代谢改变与NENs之间的关系，并探讨了针对NENs的代谢改变的潜在治疗策略。
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