Zhou Jia-Ru, Hu Xin-Yue, Liu Hong-Xing, Zhou Yu, Xiong Fei-Fei, Zhao Jian-Jun, Li Xing-Ren, Xu Gang
State Key Laboratory of Phytochemistry and Natural Medicines, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
Nat Prod Bioprospect. 2025 May 16;15(1):33. doi: 10.1007/s13659-025-00515-w.
Otteacumienes G-K (1-5), five pairs of enantiomeric diarylheptanoids, along with one undescribed diarylheptanoid glycoside and one new lignan, were isolated from Ottelia acuminata var. acuminata. Compounds 1-5 were identified as five pairs of enantiomers and their structural configurations were determined through a combination of spectroscopic analysis, X-ray crystallography, and ECD calculation. Notably, compound 6 was the first diarylheptanoid glycoside isolated from this aquatic species, and its absolute configuration was unequivocally established through semi-synthesis. Biological evaluation demonstrated that compound 1 exhibited α-glucosidase inhibitory activity, with an inhibition ratio of 38.97% (acarbose as the positive control, inhibition ratio = 13.52%).
从尖叶水车前中分离得到了耳叶水车前素G-K（1-5），五对对映体二芳基庚烷类化合物，以及一种未描述的二芳基庚烷类糖苷和一种新的木脂素。化合物1-5被鉴定为五对对映体，并通过光谱分析、X射线晶体学和ECD计算相结合的方法确定了它们的结构构型。值得注意的是，化合物6是从这种水生植物中分离得到的首个二芳基庚烷类糖苷，其绝对构型通过半合成明确确定。生物活性评价表明，化合物1表现出α-葡萄糖苷酶抑制活性，抑制率为38.97%（以阿卡波糖作为阳性对照，抑制率=13.52%）。
