通过镍催化的碳-碳键活化实现苯并环丁酮与降冰片二烯的立体选择性[2+2+2]环加成反应。
Stereoselective [2 + 2 + 2] Cycloaddition of Benzocyclobutanones and Norbornadienes through Nickel-Catalyzed C-C Bond Activation.
作者信息
Richter Robert C, Lindenmaier Ivo H, Schray David, Ströbele Markus, Fleischer Ivana
机构信息
Institute of Organic Chemistry, Faculty of Science, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 18, 72076 Tübingen, Germany.
Institute of Inorganic Chemistry, Faculty of Science, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 18, 72076 Tübingen, Germany.
出版信息
Org Lett. 2025 May 30;27(21):5385-5389. doi: 10.1021/acs.orglett.5c01324. Epub 2025 May 16.
We report a nickel-catalyzed stereoselective [2 + 2 + 2] cycloaddition between norbornadienes and benzocyclobutanones via C-C activation. This transformation generates four stereocenters, producing nortricyclane scaffolds that introduce three-dimensional architecture. The reaction proceeds with high stereoselectivity while allowing precise steric control of the reaction site, offering a versatile approach for constructing intricate stereochemical frameworks.
我们报道了一种镍催化的降冰片二烯与苯并环丁酮之间通过碳-碳活化进行的立体选择性[2 + 2 + 2]环加成反应。这种转化生成了四个立体中心，产生了引入三维结构的降三环骨架。该反应以高立体选择性进行，同时允许对反应位点进行精确的空间控制，为构建复杂的立体化学骨架提供了一种通用方法。
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