Liu Shulong, Li Jiangting, Xie Guobo
Jiangxi Provincial Chest Hospital, Nanchang, Jiangxi, China.
Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, China.
PLoS One. 2025 May 16;20(5):e0323087. doi: 10.1371/journal.pone.0323087. eCollection 2025.
This study examines how weight-adjusted waist index (WWI) correlates with the occurrence of migraine in U.S. adults.
Being overweight significantly increases the likelihood of experiencing migraines; nonetheless, conventional metrics like waist circumference (WC) and body mass index (BMI) might not completely capture the level of migraine risk tied to obesity. WWI integrates the strengths of WC while minimizing its correlation with BMI, which might make it a more accurate indicator of central obesity-related migraine susceptibility.
This study performed a cross-sectional analysis using data from 9,688 participants obtained from the National Health and Nutrition Examination Survey (NHANES), covering the years 1999-2004. Migraine occurrence was evaluated through questionnaires, and participants' WWI was computed. Weighted multivariable logistic regression models were used to examine the association between WWI and migraines. Restricted cubic splines (RCS) were applied to evaluate the dose-response relationship between WWI and migraines. Furthermore, interaction tests and subgroup analyses were executed. The receiver operating characteristic (ROC) curve, paired with DeLong et al.'s test, was employed to compare the predictive power of WWI, BMI, and WC for migraines.
The overall prevalence of migraines was found to be 21.50% (weighted population: 31,888,075 out of 148,278,824). In Model 3, the link between WWI and migraines in women showed no statistical significance (OR = 0.94, 95% CI: 0.82-1.07). In this model, each unit increase in WWI among men was linked to a 22% higher risk of migraines (OR = 1.22, 95% CI: 1.05-1.42). When stratified by quintiles, individuals in the third quintile (Q3) displayed a 69% higher likelihood of experiencing migraines compared to those in the first quintile (Q1) (OR = 1.69, 95% CI: 1.19-2.40), with a significant inflection point observed at 10.95 cm/√kg. Significant interactions were noted among various age groups (p for interaction = 0.018). WWI demonstrated a stronger predictive capability for migraine compared to BMI and WC.
A U-shaped positive correlation of WWI with migraines was observerd among adult males in the U.S., while no significant correlation was found in females. Within the context of BMI and WC, WWI exhibited a superior predictive capacity for migraines.
本研究探讨体重调整腰围指数（WWI）与美国成年人偏头痛发生之间的关联。
超重显著增加患偏头痛的可能性；然而，诸如腰围（WC）和体重指数（BMI）等传统指标可能无法完全反映与肥胖相关的偏头痛风险水平。WWI整合了WC的优势，同时将其与BMI的相关性降至最低，这可能使其成为与中心性肥胖相关的偏头痛易感性的更准确指标。
本研究使用从1999 - 2004年的美国国家健康与营养检查调查（NHANES）中获取的9688名参与者的数据进行横断面分析。通过问卷评估偏头痛的发生情况，并计算参与者的WWI。采用加权多变量逻辑回归模型来检验WWI与偏头痛之间的关联。应用受限立方样条（RCS）来评估WWI与偏头痛之间的剂量反应关系。此外，还进行了交互作用检验和亚组分析。采用受试者工作特征（ROC）曲线并结合德朗等人的检验，比较WWI、BMI和WC对偏头痛的预测能力。
发现偏头痛的总体患病率为21.50%（加权人群：148278824人中的31888075人）。在模型3中，女性中WWI与偏头痛之间的关联无统计学意义（比值比[OR]=0.94，95%置信区间[CI]：0.82 - 1.07）。在该模型中，男性中WWI每增加一个单位，患偏头痛的风险就会增加22%（OR = 1.22，95% CI：1.05 - 1.42）。按五分位数分层时，第三五分位数（Q3）的个体患偏头痛的可能性比第一五分位数（Q1）的个体高69%（OR = 1.69，95% CI：1.19 - 2.40），在10.95 cm/√kg处观察到一个显著的拐点。各年龄组之间存在显著的交互作用（交互作用p值 = 0.018）。与BMI和WC相比，WWI对偏头痛表现出更强的预测能力。
在美国成年男性中观察到WWI与偏头痛呈U形正相关，而在女性中未发现显著相关性。在BMI和WC的背景下，WWI对偏头痛表现出更好的预测能力。
