Sun Xu, Song Jimei, Yan Rixun, Diao Jianwei, Liu Yibo, Zhu Zhangzhi, Lu Weichi
Shandong University of Traditional Chinese Medicine, Jinan, China.
Guangzhou University of Chinese Medicine, Guangzhou, China.
Lipids Health Dis. 2025 Jan 11;24(1):10. doi: 10.1186/s12944-025-02432-w.
The connection between lipid-related obesity indices and severe headache or migraine in young and middle-aged people aged 20-60 remains ambiguous, and there are gaps in the discriminative ability of different indicators for severe headaches or migraines. Consequently, we set out to look into this association utilizing National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2004.
After the values of waist-to-height ratio (WHtR), body-mass index (BMI), body roundness index (BRI), visceral adiposity index (VAI), lipid accumulation product (LAP), triglyceride glucose index (TyG), cardiac metabolism index (CMI), waist triglyceride Index (WTI), conicity index (CI) and weight-adjusted waist index (WWI) were estimated, with minimal sufficient adjustment for confounders determined by directed acyclic graph (DAG), weighted univariable and multivariable logistic regression analyses were carried out to ascertain the relationship between them and migraine. Stratified analysis and cross-effect analysis were implemented to examine the variability of intergroup correlations. Restricted cubic splines (RCS) and receiver operating characteristic (ROC) were then employed to examine nonliner relationships and its discriminatory ability for severe headache or migraine, respectively.
3354 United States adults were involved in our study, of whom 839 (25.01%) had severe headache or migraine. After adjusting for relevant covariables, WHtR, BRI, BMI, LAP, WTI and VAI were all associated with migraine and WHtR (OR = 6.38, 95% CI: 2.25,18.09, P < 0.01) showed the best predictive ability. Additionally, WHtR, BMI, and BRI demonstrated linear dose-response relationships with the prevalence of migraine (all P < 0.05, P > 0.05).
Among those ten lipid-related obesity indicators evaluated in the study, WHtR, BMI and BRI demonstrated linear positive dose-response relationships with the prevalence of migraine in young and middle-aged individuals within the United States and WHtR showed the best predictive ability. Our study can provide important insight into epidemiological research and comprehensive management of obese patients with migraine.
20至60岁中青年人群中，与脂质相关的肥胖指数与严重头痛或偏头痛之间的联系仍不明确，不同指标对严重头痛或偏头痛的判别能力存在差距。因此，我们利用1999年至2004年美国国家健康和营养检查调查（NHANES）的数据来研究这种关联。
在估算腰高比（WHtR）、体重指数（BMI）、体圆度指数（BRI）、内脏脂肪指数（VAI）、脂质蓄积产物（LAP）、甘油三酯葡萄糖指数（TyG）、心脏代谢指数（CMI）、腰臀甘油三酯指数（WTI）、锥度指数（CI）和体重调整腰围指数（WWI）的值后，通过有向无环图（DAG）确定对混杂因素进行最小充分调整，进行加权单变量和多变量逻辑回归分析以确定它们与偏头痛之间的关系。实施分层分析和交叉效应分析以检验组间相关性的变异性。然后采用限制立方样条（RCS）和受试者工作特征（ROC）分别检验非线性关系及其对严重头痛或偏头痛的判别能力。
3354名美国成年人参与了我们的研究，其中839人（25.01%）患有严重头痛或偏头痛。在调整相关协变量后，WHtR、BRI、BMI、LAP、WTI和VAI均与偏头痛相关，且WHtR（OR = 6.38，95% CI：2.25，18.09，P < 0.01）显示出最佳预测能力。此外，WHtR、BMI和BRI与偏头痛患病率呈线性剂量反应关系（均P < 0.05，P > 0.05）。
在本研究评估的十个与脂质相关的肥胖指标中，WHtR、BMI和BRI在美国中青年个体中与偏头痛患病率呈线性正剂量反应关系，且WHtR显示出最佳预测能力。我们的研究可为偏头痛肥胖患者的流行病学研究和综合管理提供重要见解。
