Rhodes A R, Silverman R A, Harrist T J, Melski J W
Arch Dermatol. 1985 Oct;121(10):1266-73.
A reliable microscopic differentiation of nevomelanocytic nevi (NMNs) as congenital or acquired would be useful in defining a histogenic relationship between cutaneous melanoma and congenital NMN. In order to delineate histologic differences between congenital NMN and acquired NMN, a standardized assessment was conducted blindly, using a sample of consecutive surgical specimens of NMN submitted to a children's hospital pathology file. Despite significant histologic differences between congenital NMN and acquired NMN, the lack of a reliable prevalence rate for the proportion of congenital NMNs among all NMN specimens submitted for pathologic examination precludes a precise estimate of predictive value for diagnosing a given NMN as congenital or acquired based on histologic features alone. The results of this study can be used neither to support nor to refute a histologic association between cutaneous melanoma and congenital NMN.
将痣细胞痣（NMNs）可靠地区分为先天性或后天性，对于明确皮肤黑色素瘤与先天性NMN之间的组织发生关系会很有帮助。为了描绘先天性NMN和后天性NMN之间的组织学差异，我们采用提交给一家儿童医院病理档案的连续NMN手术标本样本，进行了盲法标准化评估。尽管先天性NMN和后天性NMN之间存在显著的组织学差异，但在提交进行病理检查的所有NMN标本中，先天性NMN所占比例缺乏可靠的患病率，这使得仅基于组织学特征来精确估计将特定NMN诊断为先天性或后天性的预测价值变得不可能。本研究结果既不能支持也不能反驳皮肤黑色素瘤与先天性NMN之间的组织学关联。
