Newton J A, Camplejohn R S, McGibbon D H
Dowling Skin Unit, St. Thomas' Hospital, London, UK.
Br J Cancer. 1988 Nov;58(5):606-9. doi: 10.1038/bjc.1988.268.
DNA flow cytometry was performed on formalin fixed, paraffin embedded melanocytic naevi. DNA aneuploidy was detected in all three types of naevus but was significantly more frequent in those naevi accepted as precursors of malignancy: that is, dysplastic and congenital pigmented hairy naevi. It may be that the presence of DNA aneuploidy has prognostic significance in these naevi. Technical problems were encountered in the analysis of data from melanocytic lesions so that caution is recommended in interpretation of studies using formalin fixed tissue.
对福尔马林固定、石蜡包埋的黑素细胞痣进行了DNA流式细胞术检测。在所有三种类型的痣中均检测到DNA非整倍体，但在被认为是恶性肿瘤前体的痣中更为常见，即发育异常痣和先天性色素性毛痣。在这些痣中，DNA非整倍体的存在可能具有预后意义。在分析黑素细胞病变的数据时遇到了技术问题，因此在解释使用福尔马林固定组织的研究时建议谨慎。
