Tsokos G C, Caughman S W, Klippel J H
Arch Dermatol. 1985 Oct;121(10):1323-5.
A 20-year-old patient had systemic lupus erythematosus and extensive generalized discoid disease that failed to respond to conventional treatment with topical steroids and high doses of hydroxychloroquine sulfate (Plaquenil). The skin lesions responded dramatically to 100 mg of azathioprine sodium daily, flared when the drug treatment was discontinued, and again responded on reinstatement of the same dosage of azathioprine. The case report suggests that extensive discoid skin lesions can be successfully treated with oral azathioprine.
一名20岁的患者患有系统性红斑狼疮和广泛的全身性盘状红斑狼疮，对局部使用类固醇和高剂量硫酸羟氯喹（羟氯喹）的常规治疗无反应。皮肤病变对每日100毫克硫唑嘌呤钠有显著反应，停药时病情复发，再次使用相同剂量的硫唑嘌呤后又有反应。该病例报告表明，口服硫唑嘌呤可成功治疗广泛的盘状皮肤病变。
